Department of Chemistry, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Korea.
ACS Macro Lett. 2022 Sep 20;11(9):1129-1135. doi: 10.1021/acsmacrolett.2c00419. Epub 2022 Aug 31.
Naturally abundant polyphenols that can readily undergo the facile cross-linking of polymer chains have been of great interest for functional hydrogel formation and its potential biomedical applications. Herein, we report that the internal incorporation of tannic acid (TA) as a natural polyphenol additive at the chitosan-based nanogel templates can enhance the self-association of physically cross-linked polymer networks upon dilution, as well as the colloidal gel stability in protein solution. This is driven by the multivalent hydrogen bonding and π-stacking capability of TA, as verified by the viscosity estimation of diluted nanogel solution, coupled to the conformation-dependent excimer emission of stacked fluorophores in polymer networks, which also allows for the Stern-Volmer analysis of the TA-induced quenching property. Furthermore, the excellent coordination generality of TA for versatile metallic cations enables the facile immobilization of a cisplatin pharmacophore inside the nanogels for acid-sensitive drug release and the potential delivery of metallic components.
天然存在的多酚很容易发生聚合物链的交联反应，因此它们在功能性水凝胶的形成及其在潜在的生物医学应用中引起了极大的关注。在此，我们报道了在基于壳聚糖的纳米凝胶模板中内部掺入单宁酸（TA）作为天然多酚添加剂，可以增强物理交联聚合物网络在稀释时的自组装，以及在蛋白质溶液中的胶体凝胶稳定性。这是由 TA 的多价氢键和π堆积能力驱动的，这可以通过稀释纳米凝胶溶液的粘度估算来验证，同时还可以结合聚合物网络中堆叠荧光团的构象依赖性激子发射进行验证，这也允许对 TA 诱导的猝灭特性进行 Stern-Volmer 分析。此外，TA 对多种金属阳离子的优异配位通用性使得可以轻松地将顺铂药效团固定在纳米凝胶内部，以实现酸敏性药物释放和潜在的金属成分递送。
