Department of Chemical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel.
Department of Chemical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel.
Carbohydr Polym. 2021 Oct 1;269:118274. doi: 10.1016/j.carbpol.2021.118274. Epub 2021 Jun 1.
This study explores hydrogels based on the physical interaction between soluble pectin and chitosan nanogels. A simple technique for creating chitosan nanogels of controllable size was developed based on a two-step process: physical cross-linking with tripolyphosphate (TPP) and chemical cross-linking with genipin. The particles were stable at acidic pH, which allowed hydrogel formation. Thixotropy experiments demonstrated that the concentration but not the size of the nanogels strongly affected the gel shear modulus. The influence of the post-assembly conditions, including exposure to monovalent salts (NaCl, NaI, and NaF) and pH (2.5 or 5.5), on the gel swelling and mechanical properties was studied. Small angle x-ray scattering (SAXS) results provide evidence that these physical hydrogels are indeed a cross-linked network. These experiments provided insights into the influence of hydrogen bonds and electrostatic interactions on the gel network.
本研究探索了基于可溶果胶与壳聚糖纳米凝胶之间物理相互作用的水凝胶。基于两步法开发了一种简单的可控尺寸壳聚糖纳米凝胶制备技术：先用三聚磷酸钠（TPP）进行物理交联，再用京尼平进行化学交联。纳米凝胶在酸性 pH 值下稳定，这允许水凝胶形成。触变实验表明，纳米凝胶的浓度而不是尺寸强烈影响凝胶的剪切模量。研究了后组装条件（包括暴露于单价盐（NaCl、NaI 和 NaF）和 pH 值（2.5 或 5.5））对凝胶溶胀和力学性能的影响。小角 X 射线散射（SAXS）结果表明，这些物理水凝胶确实是交联网络。这些实验提供了对氢键和静电相互作用对凝胶网络影响的深入了解。
