Wageningen Bioveterinary Research (WBVR), P.O. Box 65, 8200 AB, Lelystad, the Netherlands.
Wageningen Bioveterinary Research (WBVR), P.O. Box 65, 8200 AB, Lelystad, the Netherlands.
Vet Microbiol. 2019 Oct;237:108345. doi: 10.1016/j.vetmic.2019.06.018. Epub 2019 Jul 19.
We investigated whether ASF carrier pigs that had completely recovered from an acute infection with ASFV Netherlands '86, could transmit the disease to naive pigs by direct contact transmission. For this, we used pigs that had survived an ASFV infection, had recovered from disease, and had become carriers of ASFV. These clinically healthy carriers were put together one-by-one with naive contact pigs. Two of the twelve contact pigs developed an acute ASFV infection. Using the results of the experiment we quantified the transmission parameters β (0.039/day) and T (25.4 days). With the survival rate of 0.3 for our ASFV isolate, these parameter values translate into the contribution of carriers to R in groups of pigs being 0.3. Further, we placed naive contact pigs in an ASFV contaminated environment. Here, no contact infections were observed. Our findings show that clinically healthy carriers can be a source of acute new infections, which can contribute to the persistence of ASFV in swine populations. The estimates that we provide can be used for modelling of transmission in domestic pigs and, in part, for modelling transmission in wild boar.
我们研究了是否完全从 ASFV 荷兰 86 急性感染中恢复的 ASF 带毒猪能够通过直接接触传播将疾病传播给易感猪。为此，我们使用了幸存 ASF 感染、从疾病中恢复并成为 ASFV 带毒者的猪。这些临床健康的带毒者逐一与易感接触猪放在一起。十二只接触猪中有两只发展为急性 ASF 感染。根据实验结果，我们量化了传播参数β（0.039/天）和 T（25.4 天）。我们的 ASFV 分离株的存活率为 0.3，这些参数值转化为带毒猪对猪群 R 的贡献为 0.3。此外，我们将易感接触猪置于 ASFV 污染的环境中。在这里，没有观察到接触感染。我们的研究结果表明，临床健康的带毒者可能是急性新感染的来源，这可能导致 ASF 在猪群中的持续存在。我们提供的估计值可用于家猪的传播建模，部分可用于野猪的传播建模。
