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德国西部萨克森州 2015 年至 2018 年连续三个季节的乙型流感病毒感染：分子和临床特征分析。

Influenza B virus infections in Western Saxony, Germany in three consecutive seasons between 2015 and 2018: Analysis of molecular and clinical features.

机构信息

Institute of Virology, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.

Institute of Virology, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.

出版信息

Vaccine. 2019 Oct 8;37(43):6550-6557. doi: 10.1016/j.vaccine.2019.08.027. Epub 2019 Sep 11.

DOI:10.1016/j.vaccine.2019.08.027
PMID:31521415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7115636/
Abstract

BACKGROUND

The impact of annual influenza epidemics and prevailing strains varies worldwide and regional. The majority of vaccines used contained two influenza A strains and only one influenza B strain (trivalent vaccine).

AIM

The aim of the study was to compare laboratory confirmed influenza B cases during three consecutive years with respect to vaccination history, clinical symptoms and molecular virology.

METHODS

Partial HA gene sequences were analyzed for lineage determination and complete HA sequence in cases with reported vaccination and in fatal cases. Clinical data were retrieved from patient charts.

FINDINGS

During the 2015/16 season, 75 influenza B cases were retrieved; 11 in 2016/17, and 274 in 2017/18. The frequency of Yamagata-lineage strains increased from 7.6% to 100%. No difference was detected in the relative frequency of co-morbidities in season 2017/18. 37.7% of the adult patients and 4.5% of pediatric patients were vaccinated against influenza.

INTERPRETATION

Phylogenetically, Yamagata strains clustered similarly in 2017/2018 when compared to the previous two influenza seasons. While the relative frequency of influenza B cases differed, the clinical symptoms remained similar.

CONCLUSION

World Health Organization recommendations for the use of tetravalent vaccines that contain two influenza B strains (Yamagata and Victoria) in addition to the two influenza A strains (H1N1 and H3N2) should be implemented in national vaccination guidelines.

FUNDING

This research was partially supported by the Association of Sponsors and Friends of Leipzig University.

摘要

背景

全球和地区范围内，每年流感疫情和流行毒株的影响各不相同。大多数使用的疫苗含有两种甲型流感毒株和一种乙型流感毒株（三价疫苗）。

目的

本研究旨在比较连续三年实验室确诊的乙型流感病例在疫苗接种史、临床症状和分子病毒学方面的差异。

方法

对部分 HA 基因序列进行分析以确定谱系，并对报告接种疫苗和死亡病例的 HA 全长序列进行分析。临床数据从患者病历中提取。

结果

在 2015/16 季节，共检索到 75 例乙型流感病例；2016/17 年为 11 例，2017/18 年为 274 例。从 2017/18 年，Yamagata 谱系菌株的频率从 7.6%增加到 100%。在 2017/18 年季节，合并症的相对频率没有差异。成年患者中有 37.7%，儿科患者中有 4.5%接种了流感疫苗。

结论

从系统进化的角度来看，与前两个流感季节相比，2017/18 年 Yamagata 株聚类相似。虽然乙型流感病例的相对频率不同，但临床症状仍相似。

世界卫生组织建议在国家疫苗接种指南中采用包含两种乙型流感毒株（Yamagata 和 Victoria）以及两种甲型流感毒株（H1N1 和 H3N2）的四价疫苗。

资金

本研究部分得到莱比锡大学赞助者和朋友协会的支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eef/7115636/e76bc41959cc/gr3a_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eef/7115636/32b7a3a852d5/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eef/7115636/66b015f41790/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eef/7115636/e76bc41959cc/gr3a_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eef/7115636/32b7a3a852d5/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eef/7115636/66b015f41790/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eef/7115636/e76bc41959cc/gr3a_lrg.jpg

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