Aarhus University Hospital, Psychiatry, Department of Depression and Anxiety, Denmark.
Aarhus University Hospital, Psychiatry, Department of Child and Adolescent Psychiatry, Denmark.
Psychiatry Res. 2019 Nov;281:112556. doi: 10.1016/j.psychres.2019.112556. Epub 2019 Sep 4.
Weight gain is a side effect of antipsychotic medication and highly prevalent in people with schizophrenia or bipolar disorder, increasing their overall cardio-metabolic risk. We conducted a systematic review on non-pharmacological interventions for preventing/reducing weight gain or increase in waist-circumference in young, newly diagnosed patients with schizophrenia or bipolar disorder. We searched major electronic databases from inception to 04/2019 on RCTs, pre- and post-test studies, and non-randomized controlled clinical trials. From a potential of 2963 hits, eight studies met the inclusion criteria (n = 438, mean age of 18.8 (13-45) years). The interventions comprised supervised and individually adjusted aerobic exercise activities (5 studies), individual lifestyle counselling vs. control condition (2 RCTs), and dietetic counselling and practical training of cooking and shopping (1 study). Physical activity and practical dietetic interventions seem to be more efficient than lifestyle counselling. However, the results shall be taken with caution due to the non-randomized designs and other methodologically deficits in the majority of the included studies.
体重增加是抗精神病药物的副作用，在精神分裂症或双相情感障碍患者中非常普遍，增加了他们整体心血管代谢风险。我们对预防/减少年轻、新诊断的精神分裂症或双相情感障碍患者体重增加或腰围增加的非药物干预措施进行了系统评价。我们从主要的电子数据库中搜索了从成立到 2019 年 4 月的 RCT、预测试和非随机对照临床试验。在 2963 个潜在结果中，有 8 项研究符合纳入标准（n=438，平均年龄 18.8（13-45）岁）。干预措施包括监督和个体化调整的有氧运动活动（5 项研究）、个体生活方式咨询与对照组（2 项 RCT）、饮食咨询和烹饪与购物实践培训（1 项研究）。与生活方式咨询相比，体育活动和实用饮食干预似乎更有效。然而，由于大多数纳入研究的非随机设计和其他方法学缺陷，结果应谨慎对待。
