Gao Hui, Luo Chao, Tu Si-Jing, Lu Ru-Ping, Jiang Lin-Na, Qiao Hui-Jun, Lin Qu, Li Ning-Ning, Chen Jian-Hua
Department of Psychiatry, Shanghai No.1 Mental Health Center of Civil Administration, Shanghai, China.
Shanghai Institute of Traditional Chinese Medicine for Mental Health, Shanghai Clinical Research Center for Mental Health, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Psychiatry. 2021 Oct 20;12:739364. doi: 10.3389/fpsyt.2021.739364. eCollection 2021.
Patients with chronic schizophrenia present cognitive impairment, which affects their social function and prevents them from reintegrating into society. Yijinjing is a traditional Chinese aerobic exercise that has a putative psychosomatic effect on improving cognitive function. From January to May 2021, 40 patients with chronic schizophrenia were recruited and randomly divided into a control group and a Yijinjing group. In the 12-week intervention, the patients in the control group received conventional treatment, whereas patients in the Yijinjing group performed Yijinjing exercise (40 min/session, twice a week) in addition to receiving conventional treatment. The Positive and Negative Syndrome Scale (PANSS), the Insight and Treatment Attitude Questionnaire (ITAQ), the Rosenberg Self-esteem Scale (SES), and the Mini Mental State Examination (MMSE) were used to measure clinical symptoms and cognitive function at 0, 6, and 12 weeks. The demographic information was not significantly different between groups. At baseline, the scores of all the scales were not statistically different between groups. After 12 weeks of intervention, compared to those at baseline, the scores of the negative scale ( = 19.00, < 0.0001), general psychopathology scale ( = 15.98, < 0.0001), and total score ( = 15.47, < 0.0001) of the PANSS and SES ( = 5.378, < 0.0001) had significantly decreased, and the scores of the ITAQ ( = 7.984, < 0.0001) and MMSE ( = 6.750, < 0.0001) had significantly increased in Yijinjing group; the score of the MMSE increased in the control group as well ( = 2.491, = 0.0222). Compared to the respective scores in the control group, the negative scale score ( = 2.953, = 0.0054) significantly decreased, and the ITAQ ( = 3.043, = 0.0042) and MMSE ( = 2.2.68, = 0.0291) scores significantly increased in the Yijinjing group after 12 weeks of intervention. These results provide a preliminary indication that Yijinjing exercise had the potential to improve cognitive function and negative symptoms in patients with chronic schizophrenia. A larger-scale study to determine the trajectory of change in the longer term should be undertaken.
慢性精神分裂症患者存在认知障碍，这会影响他们的社交功能，使其无法重新融入社会。易筋经是一种中国传统有氧运动，对改善认知功能可能具有身心方面的作用。2021年1月至5月，招募了40例慢性精神分裂症患者，并将其随机分为对照组和易筋经组。在为期12周的干预中，对照组患者接受常规治疗，而易筋经组患者除接受常规治疗外，还进行易筋经锻炼（每次40分钟，每周两次）。使用阳性和阴性症状量表（PANSS）、领悟与治疗态度问卷（ITAQ）、罗森伯格自尊量表（SES）和简易精神状态检查表（MMSE）在第0、6和12周测量临床症状和认知功能。两组间的人口统计学信息无显著差异。基线时，所有量表的得分在两组间无统计学差异。干预12周后，与基线时相比，易筋经组PANSS的阴性量表得分（t = 19.00，p < 0.0001）、一般精神病理量表得分（t = 15.98，p < 0.0001）和总分（t = 15.47，p < 0.0001）以及SES得分（t = 5.378，p < 0.0001）显著降低，ITAQ得分（t = 7.984，p < 0.0001）和MMSE得分（t = 6.750，p < 0.0001）显著升高；对照组的MMSE得分也有所升高（t = 2.491，p = 0.0222）。干预12周后，与对照组各自的得分相比，易筋经组的阴性量表得分（t = 2.953，p = 0.0054）显著降低，ITAQ得分（t = 3.043，p = 0.0042）和MMSE得分（t = 2.68，p = 0.0291）显著升高。这些结果初步表明，易筋经锻炼有可能改善慢性精神分裂症患者的认知功能和阴性症状。应开展一项更大规模的研究来确定长期变化轨迹。
