Cosmetic Ingredient Review Scientific Analyst/Writer, Washington, DC, USA.
Cosmetic Ingredient Review Senior Director, Washington, DC, USA.
Int J Toxicol. 2019 Sep/Oct;38(2_suppl):33S-59S. doi: 10.1177/1091581819862504.
The Cosmetic Ingredient Review Expert Panel assessed the safety of 14 citrus-derived peel oil ingredients and concluded that these ingredients are safe for use in cosmetic products when finished products, excluding rinse-off products, do not contain more than 0.0015% (15 ppm) 5-methoxypsoralen, and when formulated to be nonsensitizing and nonirritating. The citrus-derived peel oil ingredients are most frequently reported to function in cosmetics as fragrances and/or skin conditioning agents. The Panel reviewed the available animal and clinical data to determine the safety of these ingredients. Because final product formulations may contain multiple botanicals, each containing the same constituents of concern, formulators are advised to be aware of these constituents and to avoid reaching levels that may be hazardous to consumers. Industry should use good manufacturing practices to limit impurities that could be present in botanical ingredients.
化妆品成分评估专家小组评估了 14 种柑橘属果皮油成分的安全性，结论认为，在成品（不包括冲洗产品）中，这些成分在化妆品中的使用是安全的，只要产品中 5-甲氧基补骨脂素的含量不超过 0.0015%（15ppm），并且配方为非致敏性和非刺激性。柑橘属果皮油成分最常被报道在化妆品中作为香料和/或皮肤调理剂发挥作用。专家组审查了现有的动物和临床数据，以确定这些成分的安全性。由于最终产品配方可能含有多种植物成分，每种成分都含有相同的关注成分，因此建议配方师了解这些成分，并避免达到可能对消费者造成危害的水平。行业应采用良好的生产规范来限制植物成分中可能存在的杂质。
