Cosmetic Ingredient Review Senior Director, Cosmetic Ingredient Review, Washington, DC, USA.
Cosmetic Ingredient Review Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA.
Int J Toxicol. 2019 Sep/Oct;38(2_suppl):5S-11S. doi: 10.1177/1091581819856568.
The Cosmetic Ingredient Review Expert Panel (Panel) reassessed the safety of 2-pyrrolidone-5-carboxylic acid (PCA) and sodium PCA; the Panel added 3 previously unreviewed salts (calcium, magnesium, and potassium) of PCA to this safety assessment. 2-Pyrrolidone-5-carboxylic acid and its salts are reported to function in cosmetics as skin conditioning agents-humectants. The Panel reviewed the data from the 1999 report of PCA and sodium PCA, as well as additional data included in this report, to determine the safety of these ingredients. The Panel concluded that PCA and its salts are safe in cosmetics in the present practices of use and concentration; additionally, these ingredients should not be used in cosmetic products in which N-nitroso compounds can be formed.
化妆品成分评估专家小组（专家组）重新评估了 2-吡咯烷酮-5-羧酸（PCA）和 PCA 钠盐的安全性；专家组将 PCA 的 3 种以前未审查的盐（钙、镁和钾）纳入了本次安全性评估。据报道，2-吡咯烷酮-5-羧酸及其盐在化妆品中用作皮肤调理剂-保湿剂。专家组审查了 1999 年 PCA 和 PCA 钠盐报告中的数据，以及本报告中包含的其他数据，以确定这些成分的安全性。专家组得出结论，PCA 及其盐在目前使用和浓度的化妆品中使用是安全的；此外，这些成分不应用于可能形成亚硝胺化合物的化妆品产品中。
