Fiume Monice M, Bergfeld Wilma F, Belsito Donald V, Hill Ronald A, Klaassen Curtis D, Liebler Daniel C, Marks James G, Shank Ronald C, Slaga Thomas J, Snyder Paul W, Gill Lillian J, Heldreth Bart
Cosmetic Ingredient Review Senior Director.
Expert Panel for Cosmetic Ingredient Safety Member.
Int J Toxicol. 2021 Oct;40(2_suppl):117S-133S. doi: 10.1177/10915818211023881. Epub 2021 Jul 6.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 5 acyl sarcosines and 9 sarcosinate salts as used in cosmetics; all of these ingredients are reported to function in cosmetics as hair conditioning agents and most also can function as surfactants-cleansing agents. The ingredients reviewed in this assessment are composed of an amide comprising a fatty acyl residue and sarcosine and are either free acids or simple salts thereof. The Panel relied on relevant new data, including concentration of use, and considered data from the previous Panel report, such as the reaction of sarcosine with oxidizing materials possibly resulting in nitrosation and the formation of -nitrososarcosine. The Panel concluded that these ingredients are safe as used in cosmetics when formulated to be non-irritating, but these ingredients should not be used in cosmetic products in which -nitroso compounds may be formed.
化妆品成分安全专家小组（小组）评估了化妆品中使用的5种酰基肌氨酸和9种肌氨酸盐的安全性；据报道，所有这些成分在化妆品中起头发调理剂的作用，大多数还可以起表面活性剂 - 清洁剂的作用。本次评估中审查的成分由包含脂肪酰基残基和肌氨酸的酰胺组成，它们要么是游离酸，要么是其简单盐。小组依赖于相关的新数据，包括使用浓度，并参考了小组先前报告中的数据，例如肌氨酸与可能导致亚硝化作用并形成亚硝基肌氨酸的氧化材料的反应。小组得出结论，当配方为无刺激性时，这些成分在化妆品中的使用是安全的，但这些成分不应在可能形成亚硝基化合物的化妆品中使用。
