Knoll J, Gyires K, Mészáros Z
Arzneimittelforschung. 1979;29(5):766-73.
1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido[1,2-a]pyrimidine-3-carbamide (Chinoin 127), a non-narcotic analgesic with potent antiinflammatory activity is described. Chinoin-127 is more potent as an analgesic in the hot plate, Randall-Selitto and writhing tests than is acetylsalicylic acid (ASA) and an effective antiphlogistic agent in a battery of tests (carrageenin, kaolin and dextran induced rat paw edema, Northover test, carrageenin induced abscess, implanted cotton pellet method, adjuvant arthritis) used for measuring antiinflammatory activity. The PG-synthesis inhibitors (indometacin, suprofen) were found to be devoid of analgesic activity, and great test-dependent variations in their antiinflammatory effect were observed. They proved to be inactive in the Northover test. Unusual grade of inhibition in the carrageenin-induced rat paw edema test was obtainable by the simultaneous administration of Chinoin 127 and indometacin.
1,6 - 二甲基 - 4 - 氧代 - 1,6,7,8,9,9a - 六氢 - 4H - 吡啶并[1,2 - a]嘧啶 - 3 - 甲酰胺（奇诺因127），一种具有强效抗炎活性的非麻醉性镇痛药被描述。在热板法、兰德尔 - 塞利托法和扭体试验中，奇诺因 - 127作为镇痛药比乙酰水杨酸（ASA）更有效，并且在一系列用于测量抗炎活性的试验（角叉菜胶、高岭土和右旋糖酐诱导的大鼠足肿胀、诺思弗试验、角叉菜胶诱导的脓肿、植入棉球法、佐剂性关节炎）中是一种有效的抗炎剂。发现PG合成抑制剂（吲哚美辛、舒洛芬）没有镇痛活性，并且观察到它们的抗炎作用有很大的试验依赖性差异。它们在诺思弗试验中被证明是无活性的。通过同时给予奇诺因127和吲哚美辛，在角叉菜胶诱导的大鼠足肿胀试验中可获得不同寻常程度的抑制。
