Cooper Medical School of Rowan University , Camden , New Jersey 08103-1211 , United States.
Developmental BioEngineering (DBE) , The University of Twente , 7522 NB Enschede , Netherlands.
ACS Appl Mater Interfaces. 2019 Oct 23;11(42):38373-38384. doi: 10.1021/acsami.9b08757. Epub 2019 Oct 14.
Adhesion to wet and dynamic surfaces is vital for many biomedical applications. However, the development of effective tissue adhesives has been challenged by the required combination of properties, which includes mechanical similarity to the native tissue, high adhesion to wet surfaces, hemostatic properties, biodegradability, high biocompatibility, and ease of use. In this study, we report a novel bioinspired design with bioionic liquid (BIL) conjugated polymers to engineer multifunctional highly sticky, biodegradable, biocompatible, and hemostatic adhesives. Choline-based BIL is a structural precursor of the phospholipid bilayer in the cell membrane. We show that the conjugation of choline molecules to naturally derived polymers (i.e., gelatin) and synthetic polymers (i.e., polyethylene glycol) significantly increases their adhesive strength and hemostatic properties. Synthetic or natural polymers and BILs were mixed at room temperature and cross-linked via visible light photopolymerization to make hydrogels with tunable mechanical, physical, adhesive, and hemostatic properties. The hydrogel adhesive exhibits a close to 50% decrease in the total blood volume loss in tail cut and liver laceration rat animal models compared to the control. This technology platform for adhesives is expected to have further reaching application vistas from tissue repair to wound dressings and the attachment of flexible electronics.
粘附在潮湿和动态的表面对于许多生物医学应用至关重要。然而，有效的组织胶粘剂的开发受到所需性能组合的挑战，这些性能包括与天然组织的机械相似性、对潮湿表面的高粘附性、止血性能、可生物降解性、高生物相容性和使用方便性。在这项研究中，我们报告了一种具有生物离子液体（BIL）共轭聚合物的新型仿生设计，用于工程多功能高粘性、可生物降解、生物相容和止血胶粘剂。胆碱基 BIL 是细胞膜中磷脂双层的结构前体。我们表明，胆碱分子与天然衍生聚合物（即明胶）和合成聚合物（即聚乙二醇）的共轭显著提高了它们的粘附强度和止血性能。合成或天然聚合物和 BIL 在室温下混合，并通过可见光光聚合交联，以制造具有可调机械、物理、粘附和止血性能的水凝胶。与对照组相比，水凝胶胶粘剂在尾部切割和肝脏撕裂大鼠动物模型中总失血量减少近 50%。这种用于胶粘剂的技术平台有望在组织修复、伤口敷料和柔性电子产品的附着等方面得到更广泛的应用。
