Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia.
Ural State Agrarian University, Yekaterinburg, Russia.
Curr Pharm Biotechnol. 2024;25(15):2022-2031. doi: 10.2174/0113892010269503231229100317.
Nanocomposite glycerohydrogels based on biocompatible elementcontaining glycerolates are of practicular interest for biomedical applications.
Using two biocompatible precursors, silicon and iron glycerolates, a new bioactive nanocomposite silicon‒iron glycerolates hydrogel was obtained by sol-gel method.
The composition and structural features of the hydrogel were studied using a complex of modern analytical techniques, including TEM, XRD, and AES. On the example of experimental animals hemostatic activity of the hydrogel was studied, as well as primary toxicological studies were carried out.
The composition of dispersed phase and dispersion medium of silicon‒iron glycerolates hydrogel was determined. The structural features of hydrogel were revealed and its structure model was proposed. It was shown that silcon-iron glycerolates hydrogel is nontoxic, and exhibits pronounced hemostatic activity.
Silicon-iron glycerolates hydrogel is a potential hemostatic agent for topical application in medical and veterinary practice.
基于生物相容元素甘油酸盐的纳米复合甘油水凝胶在生物医学应用中具有特殊的应用价值。
使用两种生物相容的前体，硅和铁甘油酸盐，通过溶胶-凝胶法获得了一种新的生物活性纳米复合硅-铁甘油酸盐水凝胶。
使用一系列现代分析技术，包括 TEM、XRD 和 AES，研究了水凝胶的组成和结构特征。以实验动物为例，研究了水凝胶的止血活性，并进行了初步的毒理学研究。
确定了硅-铁甘油酸盐水凝胶的分散相和分散介质的组成。揭示了水凝胶的结构特征，并提出了其结构模型。结果表明，硅-铁甘油酸盐水凝胶是无毒的，并表现出明显的止血活性。
硅-铁甘油酸盐水凝胶是一种潜在的局部止血剂，可用于医学和兽医实践。
