Department of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.
Org Lett. 2019 Oct 4;21(19):8027-8030. doi: 10.1021/acs.orglett.9b03015. Epub 2019 Sep 16.
Synthesis of the fused polycyclic ether motif comprising the rings of the marine ladder polyethers tamulamides A and B has been achieved via two different etherification strategies. Ultimately, a reductive etherification approach proved most successful due to tolerance of the ring substitution and provided the 6,7,6 ring system in 58% yield.
通过两种不同的醚化策略，实现了包含海洋梯型聚醚类化合物 tamulamides A 和 B 的 环的稠合多环醚基元的合成。最终，由于对 环取代基的容忍度，还原醚化方法最为成功，以 58%的收率提供了 6,7,6 环系统。
