College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, People's Republic of China.
Fujian Colleges and University Engineering Research Institute of Conservation & Utilization of Natural Bioresources, Fujian Agriculture and Forestry University, Fuzhou, People's Republic of China.
Nat Prod Res. 2021 Jul;35(13):2184-2189. doi: 10.1080/14786419.2019.1666387. Epub 2019 Sep 16.
Two new alkaloids, named hositisines A () and B (), with two known alkaloids ( and ) were isolated from the stems of Hemsl. et Wils. Their structures were confirmed by UV, HRESIMS, NMR spectra. The absolute configurations of and were determined by quantum ECD calculation and ECD, respectively. Compounds - could significantly reduce the LDH release at the concentration 50 μM, which showed they could strongly protect the PC12 cells exposed to oxygen and glucose deprivation/reoxygenation (OGD/R) injury.
从 Hemsl. et Wils. 的茎中分离得到两个新的生物碱，命名为 hositisines A () 和 B ()，并与两个已知生物碱（和）一起分离得到。通过 UV、HRESIMS、NMR 光谱确定了它们的结构。通过量子 ECD 计算和 ECD 分别确定了和的绝对构型。化合物 - 在 50μM 的浓度下可显著降低 LDH 的释放，表明它们可强烈保护暴露于氧葡萄糖剥夺/复氧 (OGD/R) 损伤的 PC12 细胞。
