College of Pharmacy, Fujian Key laboratory of Chinese Materia Medica, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
J Pharm Biomed Anal. 2023 Mar 20;226:115238. doi: 10.1016/j.jpba.2023.115238. Epub 2023 Jan 10.
Ormosia hosiei Hemsl. et Wils. is an economical and medicinal plant, increasingly cultivated in China; however, its branches and leaves are often pruned as waste. This is the first study focused on the phytochemical profiles and antioxidant, anti-α-glucosidase, anti-tyrosinase, and anti-neuroinflammatory activities of the branches and leaves of O. hosiei. Herein, thirty-seven characteristic compounds were identified by UPLC-MS/MS and twelve were detected for the first time in O. hosiei. Twenty-seven phenolics were further quantified and significant differences in phenolic compositions between the branches and leaves of O. hosiei were observed. The ethanol extracts exhibited promising antioxidant, anti-α-glucosidase, anti-tyrosinase, and anti-neuroinflammatory effects, and the bioactivities significantly correlated with total phenolic content and twelve individual phenolics. Naringin, genistein, vitexin, vitexin-2-O-rhamnoside, syringaresinol and syringaresinol-4-O-β-D-glucopyranoside can be considered potential quality markers of O. hosiei. Our results provided solid evidence that the branches and leaves of O. hosiei deserve more attention and exploitation, considering the potential to be developed as functional foods or herbal medicines.
胡桐（Ormosia hosiei Hemsl. et Wils.）是一种经济和药用植物，在中国越来越多地被种植；然而，其树枝和树叶常被修剪为废弃物。这是首次针对胡桐树枝和树叶的植物化学特征以及抗氧化、抗α-葡萄糖苷酶、抗酪氨酸酶和抗神经炎症活性进行研究。在此，通过 UPLC-MS/MS 鉴定了 37 种特征化合物，其中 12 种是在胡桐中首次检测到的。进一步定量了 27 种酚类化合物，并观察到胡桐树枝和树叶之间酚类成分的显著差异。乙醇提取物表现出有希望的抗氧化、抗α-葡萄糖苷酶、抗酪氨酸酶和抗神经炎症活性，生物活性与总酚含量和 12 种个体酚类物质显著相关。柚皮苷、染料木素、牡荆素、牡荆素-2-O-鼠李糖苷、丁香树脂醇和丁香树脂醇-4-O-β-D-吡喃葡萄糖苷可以被认为是胡桐的潜在质量标志物。我们的研究结果提供了确凿的证据，表明胡桐的树枝和树叶值得更多的关注和开发，可以考虑将其开发为功能性食品或草药。
