将抗癌药物原位冷凝到纤维蛋白凝胶中，从而有效抑制肿瘤细胞生长。

In situ condensation of an anti-cancer drug into fibrin gel enabling effective inhibition of tumor cell growth.

机构信息

Graduate School of Integrated Basic Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan.

Department of Internal Medicine, Division of Endocrinology and Metabolism, Graduate School of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, 371-8511, Japan.

出版信息

Chem Commun (Camb). 2019 Oct 7;55(78):11679-11682. doi: 10.1039/c9cc06418d. Epub 2019 Sep 16.

DOI:10.1039/c9cc06418d

PMID:31524892

Abstract

We show herein the highly effective inhibition of tumor cell growth using a gel consisting of a fibrin polymer formed with the in situ condensation of a camptothecin (CPT) derivative as an anti-cancer drug, which is efficiently conveyed with a carrier aptamer from a solution to the gel in a phenomenon, called selective oligonucleotide entrapment in fibrin polymers (SOEF).

摘要

我们在此展示了一种由纤维蛋白聚合物组成的凝胶的高效抑制肿瘤细胞生长的效果，该聚合物是通过原位缩合一种喜树碱（CPT）衍生物作为抗癌药物形成的，这种药物在一种称为纤维蛋白聚合物中选择性寡核苷酸捕获（SOEF）的现象中，通过载体适配体从溶液中有效地传递到凝胶中。