Girotti Alessandra, Escalera-Anzola Sara, Alonso-Sampedro Irene, González-Valdivieso Juan, Arias Francisco Javier
BIOFORGE Research Group (Group for Advanced Materials and Nanobiotechnology), CIBER-BBN, University of Valladolid, LUCIA Building, 47011 Valladolid, Spain.
Recombinant Biomaterials Research Group, University of Valladolid, LUCIA Building, 47011 Valladolid, Spain.
Pharmaceutics. 2020 Nov 19;12(11):1115. doi: 10.3390/pharmaceutics12111115.
Biomaterials science is one of the most rapidly evolving fields in biomedicine. However, although novel biomaterials have achieved well-defined goals, such as the production of devices with improved biocompatibility and mechanical properties, their development could be more ambitious. Indeed, the integration of active targeting strategies has been shown to allow spatiotemporal control of cell-material interactions, thus leading to more specific and better-performing devices. This manuscript reviews recent advances that have led to enhanced biomaterials resulting from the use of natural structural macromolecules. In this regard, several structural macromolecules have been adapted or modified using biohybrid approaches for use in both regenerative medicine and therapeutic delivery. The integration of structural and functional features and aptamer targeting, although still incipient, has already shown its ability and wide-reaching potential. In this review, we discuss aptamer-functionalized hybrid protein-based or polymeric biomaterials derived from structural macromolecules, with a focus on bioresponsive/bioactive systems.
生物材料科学是生物医学中发展最为迅速的领域之一。然而，尽管新型生物材料已实现了明确的目标，如生产具有改善的生物相容性和机械性能的装置，但其发展仍可更加雄心勃勃。事实上，活性靶向策略的整合已被证明能够实现细胞与材料相互作用的时空控制，从而产生更具特异性和性能更优的装置。本手稿综述了近期利用天然结构大分子从而增强生物材料的进展。在这方面，几种结构大分子已通过生物杂交方法进行了改造或修饰，用于再生医学和治疗递送。结构与功能特征以及适配体靶向的整合，尽管仍处于初期阶段，但已展现出其能力和广泛的潜力。在本综述中，我们讨论源自结构大分子的基于适配体功能化杂合蛋白或聚合物的生物材料，重点关注生物响应/生物活性系统。
