Dipartimento Strutturale Medicina di Laboratorio, Azienda Ospedale Università di Padova, Padova, Italy.
Direttore Scientifico, IRCCS Istituto Ortopedico Galeazzi, Università Vita e Salute San Raffaele, Milan, Italy.
Clin Chem Lab Med. 2020 Jan 28;58(2):178-187. doi: 10.1515/cclm-2019-0719.
Serum or plasma? An old question looking for new answers. There is a continual debate on what type of sample a clinical laboratory should use. While serum is still considered the gold standard and remains the required sample for some assays, laboratories must consider turn-around time, which is an important metric for laboratory performance and, more importantly, plays a critical role in patient care. In addition, a body of evidence emphasise the choice of plasma in order to prevent modifications of some analytes due to the coagulation process and related interferences. Advantages and disadvantages of serum and plasma are discussed on the basis of current literature and evidence. In addition, data are provided on the current utilisation of the samples (serum or plasma) in Italy and in other countries. Finally, a rationale for a possible switch from serum to plasma is provided.
血清还是血浆？一个古老的问题，寻求新的答案。关于临床实验室应该使用哪种样本，一直存在争议。虽然血清仍然被认为是金标准，并且仍然是一些检测的必需样本，但实验室必须考虑周转时间，这是实验室性能的一个重要指标，更重要的是，在患者护理中起着关键作用。此外，越来越多的证据强调选择血浆，以防止由于凝血过程和相关干扰而导致某些分析物发生变化。本文根据现有文献和证据讨论了血清和血浆的优缺点。此外，还提供了关于意大利和其他国家目前使用样本（血清或血浆）的数据。最后，提供了从血清转换为血浆的可能理由。
