Effectiveness of using an extensively hydrolyzed casein formula supplemented with GG compared with an extensively hydrolysed whey formula in managing cow's milk protein allergic infants.

To assess the comparative effectiveness of two hypoallergenic formulae in managing cow's milk allergic infants. This study retrospectively analyzed the case records of 940 formula-fed cow's milk allergic infants in the UK extracted from The Health Improvement Network database. At 24 months after starting a formula, 77% of infants fed an extensively hydrolyzed casein formula supplemented with GG (eHCF LGG; n = 470) were estimated to have been successfully managed compared with 63% of matched infants who were fed an extensively hydrolyzed whey formula (eHWF; n = 470; p < 0.001). Additionally, significantly more eHWF-fed infants were estimated to be experiencing gastrointestinal symptoms, eczema and asthma (7.1 vs 3.1%; p < 0.02) at 24 months. First-line management of newly diagnosed cow's milk allergic infants with eHCF LGG may slow down the allergic march seen in cow's milk allergic children.