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用于药物分析的基于碳纳米结构的电化学传感器的开发。

Development of Carbon Nanostructured Based Electrochemical Sensors for Pharmaceutical Analysis.

作者信息

Ghalkhani Masoumeh, Ghorbani-Bidkorbeh Fatemeh

机构信息

Department of Chemistry, Faculty of Science, Shahid Rajaee Teacher Training University, Lavizan, Tehran, Iran.

Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Iran J Pharm Res. 2019 Spring;18(2):658-669. doi: 10.22037/ijpr.2019.1100645.

Abstract

Pharmaceutical drugs play an important role in human life since they caused a revolution in human health. Notably, their administration to a living organism helps body to stay healthy. Commonly, they are employed to diagnose, prevent, or treat and cure a disease via a biological effect on a human body. Administration of impurityfree and adequate amounts of pharmaceutical compounds would be beneficial. Therefore, the quantity and purity of the substances in pharmaceutical compounds are continuously monitored during drug manufacturing with various chemical or instrumental analysis techniques. The possibility of impurities development and chemical or quantity changes of active drug species at various stages (namely during production, transportation or storage) makes them redundant and risky for human health. So, sensitive and accurate analysis methods for qualitative and quantitative analysis are highly demanded by pharmaceutical companies and medical centers. The present mini review emphasizes on application of carbon based modified electrodes in health care and pharmaceutical analysis. Electrochemical determination of drugs employing carbon nanostructured modified electrodes will be reviewed and their advantages and disadvantages will be mentioned.

摘要

药物在人类生活中发挥着重要作用,因为它们引发了人类健康领域的一场革命。值得注意的是,将药物施用于生物体有助于身体保持健康。通常,它们通过对人体产生生物学效应来诊断、预防、治疗和治愈疾病。施用无杂质且适量的药物化合物将是有益的。因此,在药物制造过程中,使用各种化学或仪器分析技术持续监测药物化合物中物质的数量和纯度。在各个阶段(即在生产、运输或储存期间),杂质产生以及活性药物种类发生化学或数量变化的可能性使其变得多余且对人类健康有风险。所以,制药公司和医疗中心对用于定性和定量分析的灵敏且准确的分析方法有很高的需求。本微型综述着重介绍碳基修饰电极在医疗保健和药物分析中的应用。将综述采用碳纳米结构修饰电极对药物进行电化学测定,并提及它们的优缺点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb4/6706716/e57eee938cc8/ijpr-18-658-g001.jpg

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