Al-Nami Samar Y, Alorabi Ali Q, Al-Ahmed Zehbah A, Mogharbel Amal T, Abumelha Hana M, Hussein Mohammed A, El-Metwaly Nashwa M
Department of Chemistry, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61421, Saudi Arabia.
Department of Chemistry, Faculty of Sciences, Albaha University, P.O. Box 1988, Albaha 65799, Saudi Arbia.
ACS Omega. 2023 Mar 9;8(11):10449-10458. doi: 10.1021/acsomega.3c00040. eCollection 2023 Mar 21.
The present work demonstrated the fabrication and the electrochemical characterization of novel printed electrochemical sensors integrated with an innovative nanosensing platform based on the synergic electrocatalytic effect of iron oxide nanoparticles (FeONPs) and reduced graphene oxide (rGO) for precise voltammetric determination of the antipsychotic drug lurasidone hydrochloride (LUH). The features of the electrode surface fabricated using the ordinary inkjet printer were characterized by scanning electron microscopy and electrochemical impedance spectroscopy. Among different ink formulations, integration of the printing ink with the ratio 15 mg FeONPs and 20 mg rGO was found to be the most appropriate for sensitive quantification of LUH in biological fluids and pharmaceutical formulations in the presence of LUH degradation products. Under the optimized experimental and electroanalytical parameters, the recorded square-wave voltammograms were correlated to LUH within the linear concentration ranging from 50 to 2150 ng mL with detection limit and limit of quantification values of 15.64 and 47.39 ng mL, respectively. Based on the cyclic voltammograms recorded for LUH at different scan rates, the electrode reaction was assumed to be a diffusion reaction mechanism accompanied by the transfer of two electrons/protons through the oxidation of the five-membered ring nitrogen atom as assumed by the molecular orbital calculations carried out on the LUH molecule. The of LUH and the efficiency of the fabricated sensors enabled their clinical application for monitoring LUH in human biological fluids and pharmaceutical formulations in the presence of degradants for diverse quality control applications and green chemistry analysis.
本工作展示了新型印刷电化学传感器的制备及其电化学表征，该传感器集成了基于氧化铁纳米颗粒（FeONPs）和还原氧化石墨烯（rGO）协同电催化效应的创新纳米传感平台，用于精确伏安法测定抗精神病药物盐酸鲁拉西酮（LUH）。使用普通喷墨打印机制造的电极表面特征通过扫描电子显微镜和电化学阻抗谱进行表征。在不同的油墨配方中，发现含有15 mg FeONPs和20 mg rGO比例的印刷油墨最适合在存在LUH降解产物的情况下对生物流体和药物制剂中的LUH进行灵敏定量。在优化的实验和电分析参数下，记录的方波伏安图与LUH在50至2150 ng/mL的线性浓度范围内相关，检测限和定量限分别为15.64和47.39 ng/mL。基于在不同扫描速率下记录的LUH循环伏安图，电极反应被认为是一种扩散反应机制，伴随着通过LUH分子上五元环氮原子的氧化转移两个电子/质子，这是对LUH分子进行分子轨道计算所假设的。LUH的 以及所制备传感器的效率使其能够在存在降解产物的情况下用于临床监测人体生物流体和药物制剂中的LUH，以用于各种质量控制应用和绿色化学分析。
