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[具体因素]对新生儿高胆红素血症的影响：一项系统评价和荟萃分析。 （原文中“Effect of on”部分缺少具体因素，这里补充了“[具体因素]”以使译文完整）

Effect of on Neonatal Hyperbilirubinemia: A Systematic Review and Meta-analysis.

作者信息

Sajedi Firoozeh, Fatollahierad Shiva

机构信息

Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

出版信息

Iran J Pharm Res. 2019 Spring;18(2):1020-1031. doi: 10.22037/ijpr.2019.2388.

DOI:10.22037/ijpr.2019.2388
PMID:31531082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6706735/
Abstract

The aim of this systematic review was to evaluate the effect of on the unconjugated hyperbilirubinemia in neonates. Pubmed, Scopus, Chochrane library, Iranmedex and Google scholar were last searched in February 2017. Randomized controlled trials that evaluated the effect of on the treatment of neonatal hyperbilirubinemia were included in the review. For meta-analysis, weighted mean difference (WMD) with 95% confidence interval (CI) was used. The outcomes of interests were serum bilirubin levels and length of hospital stay in neonates with jaundice. Seven randomized controlled trials with 812 neonates were eligible to be included in this systematic review. The meta-analysis included six of seven controlled trials. Bilirubin levels were significantly lower at 12 h (WMD: -1.48, 95% CI: -2.31 to -0.65), 24 h (WMD: -2.47, 95% CI: -3.22 to -1.71), 36 h (WMD: -2.83, 95% CI: -4.87 to -0.80), 48 h (WMD: -1.49, 95% CI: -2.36 to -0.63) and 72 h (WMD: -0.68, 95% CI: -1.28 to -0.08) following intervention in group. Length of hospital stay was also decreased in group (WMD: -0.93, 95% CI: -1.35 to -0.50). Finally, administration decreased serum bilirubin level and length of hospital stay in neonates with unconjugated hyperbilirubinemia. More studies are needed to evaluate the efficacy, dosage, and side effects of .

摘要

本系统评价的目的是评估[具体干预措施]对新生儿非结合胆红素血症的影响。2017年2月对PubMed、Scopus、Cochrane图书馆、Iranmedex和谷歌学术进行了最新检索。纳入本评价的是评估[具体干预措施]对新生儿高胆红素血症治疗效果的随机对照试验。进行荟萃分析时，采用了95%置信区间（CI）的加权平均差（WMD）。感兴趣的结局是黄疸新生儿的血清胆红素水平和住院时间。七项涉及812例新生儿的随机对照试验符合纳入本系统评价的条件。荟萃分析纳入了七项对照试验中的六项。在[干预措施]组干预后12小时（WMD：-1.48，95%CI：-2.31至-0.65）、24小时（WMD：-2.47，95%CI：-3.22至-1.71）、36小时（WMD：-2.83，95%CI：-4.87至-0.80）、48小时（WMD：-1.49，95%CI：-2.36至-0.63）和72小时（WMD：-0.68，95%CI：-1.28至-0.08）时，胆红素水平显著降低。[干预措施]组的住院时间也缩短了（WMD：-0.93，95%CI：-1.35至-0.50）。最后，[干预措施]的应用降低了非结合胆红素血症新生儿的血清胆红素水平和住院时间。需要更多研究来评估[干预措施]的疗效、剂量和副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/64b3779e8ced/ijpr-18-1020-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/e7d2ea8cc091/ijpr-18-1020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/4acc22faaa97/ijpr-18-1020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/704e3e194c76/ijpr-18-1020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/13e68d52593c/ijpr-18-1020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/e78724fe0026/ijpr-18-1020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/c1c90a336ddf/ijpr-18-1020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/34e58c702171/ijpr-18-1020-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/5a9fece93606/ijpr-18-1020-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/64b3779e8ced/ijpr-18-1020-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/e7d2ea8cc091/ijpr-18-1020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/4acc22faaa97/ijpr-18-1020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/704e3e194c76/ijpr-18-1020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/13e68d52593c/ijpr-18-1020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/e78724fe0026/ijpr-18-1020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/c1c90a336ddf/ijpr-18-1020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/34e58c702171/ijpr-18-1020-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/5a9fece93606/ijpr-18-1020-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8154/6706735/64b3779e8ced/ijpr-18-1020-g009.jpg

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