Najib Khadije Sadat, Saki Forough, Hemmati Fariba, Inaloo Soroor
Namazi Hospital, Shiraz University of medical sciences, Shiraz, IR Iran.
Iran Red Crescent Med J. 2013 Mar;15(3):260-3. doi: 10.5812/ircmj.3337. Epub 2013 Mar 5.
Today, Severe hyperbilirubinemia is the most common cause of neonatal readmissions. Identification of the cause of neonatal hyperbilirubinemia is useful in determining whether therapeutic interventions can prevent severe hyperbilirubinemia.
We conducted this study to estimate the incidence of severe hyperbilirubinemia in Fars province and to determine the underlying causes and risk factors, which would be of value in identifying and implementing strategies to prevent morbidity from this condition.
All infants less than 28 days referred due to severe indirect hyperbilirubinemia were included. Complete history, physical examination and lab work up were performed. This is a longitudinal prospective study in 2009-2010.
More common causes of severe indirect hyperbilirubinemia were blood group incompatibility, G6PD deficiency, sepsis and unknown. Risk factors of severe hyperbilirubinemia were Male sex, previous siblings with severe hyperbilirubinemia, early discharge, NVD, Breast feeding and cultural background of mothers.
Our study showed severe neonate indirect hyperbilirubinemia is still prevalence in Fars province and ethnic and cultural background of the mothers was more effective than school education in preventing hyperbilirubinemia complication.
如今，重度高胆红素血症是新生儿再次入院的最常见原因。确定新生儿高胆红素血症的病因有助于判断治疗干预措施能否预防重度高胆红素血症。
我们开展这项研究以估算法尔斯省重度高胆红素血症的发病率，并确定其潜在病因和风险因素，这对于识别和实施预防该病症发病的策略具有重要价值。
纳入所有因重度间接高胆红素血症转诊的28日龄以内婴儿。进行了完整的病史采集、体格检查及实验室检查。这是一项2009年至2010年的纵向前瞻性研究。
重度间接高胆红素血症更常见的病因是血型不合、葡萄糖-6-磷酸脱氢酶（G6PD）缺乏、败血症及病因不明。重度高胆红素血症的风险因素包括男性、有重度高胆红素血症患儿的同胞、早期出院、自然分娩、母乳喂养及母亲的文化背景。
我们的研究表明，重度新生儿间接高胆红素血症在法尔斯省仍然普遍存在，母亲的种族和文化背景在预防高胆红素血症并发症方面比学校教育更有效。
