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70岁以上成年人的脊柱畸形:一项为期两年的随访研究。

Adult Spinal Deformity Over 70 Years of Age: A 2-Year Follow-Up Study.

作者信息

Karabulut Cem, Ayhan Selim, Yuksel Selcen, Nabiyev Vugar, Vila-Casademunt Alba, Pellise Ferran, Alanay Ahmet, Perez-Grueso Francisco Javier Sanchez, Kleinstuck Frank, Obeid Ibrahim, Acaroglu Emre

机构信息

ARTES Spine Center, Ankara, Turkey.

Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

出版信息

Int J Spine Surg. 2019 Aug 31;13(4):336-344. doi: 10.14444/6046. eCollection 2019 Aug.

Abstract

BACKGROUND

Treatment of adult spinal deformity (ASD) in elderly patients remains controversial. The aim of this study was to identify the factors leading to the surgical treatment by comparing the baseline characteristics of operative versus nonoperative patients, to evaluate the safety and efficacy of surgery, and to compare operative and nonoperative management of elderly ASD patients at the end of the 2-year follow-up period.

METHODS

Retrospective review of a multicenter, prospective ASD database was performed. Patients over 70 years of age with ASD who were scheduled to undergo surgical treatment and who were treated and/or followed without surgical intervention participated in the study. Demographic, clinical, surgical, and radiological characteristics and health-related quality-of-life (HRQOL) (Core Outcome Measures Index [COMI], Oswestry Disability Index [ODI], Short-Form-36 Mental Component Summary [SF-36 MCS], Short-Form-36 Physical Component Summary [SF36-PCS], and Scoliosis Research Society-22 [SRS-22]) parameters of such group of patients were evaluated pre- and posttreatment.

RESULTS

A total 90 patients (females: 71, males: 29; operative: 61, nonoperative: 29) made up the study group. The comparison between the operative and the nonoperative groups at baseline showed statistical significance for all the HRQOL parameters and the major coronal Cobb angle ( < .05). The calculated optimal cutoff values to diverge operative and nonoperative groups for COMI, ODI, SF-36 PCS, and SRS-22 were 5.7, 37.0, 37.5, and 3.2, respectively ( < .05). All operative patients were treated with posterior surgery. Overall, 135 complications (71 major, 64 minor) and 1 death were observed. Surgically treated patients were found to be improved both clinically and in HRQOL parameters 2 years after surgery for all HRQOL parameters except SF-36 MCS, even in the presence of complications ( < .05), while nonoperative patients have not changed or deteriorated at the end of 2 years.

CONCLUSIONS

Despite a relatively high incidence of complications, the likelihood of achieving a clinically significant and relevant HRQOL improvement was superior for patients who were treated surgically in the present population.

摘要

背景

老年患者成人脊柱畸形(ASD)的治疗仍存在争议。本研究的目的是通过比较手术患者与非手术患者的基线特征,确定导致手术治疗的因素,评估手术的安全性和有效性,并在2年随访期结束时比较老年ASD患者的手术和非手术治疗情况。

方法

对一个多中心前瞻性ASD数据库进行回顾性研究。纳入70岁以上计划接受手术治疗以及接受了非手术治疗和/或随访的ASD患者。在治疗前后评估该组患者的人口统计学、临床、手术和放射学特征以及健康相关生活质量(HRQOL)(核心结局指标指数[COMI]、奥斯威斯利功能障碍指数[ODI]、简短健康调查问卷精神成分总结[SF-36 MCS]、简短健康调查问卷身体成分总结[SF36-PCS]和脊柱侧弯研究学会-22[SRS-22])参数。

结果

共有90例患者(女性:71例,男性:29例;手术组:61例,非手术组:29例)组成研究队列。手术组和非手术组在基线时的比较显示,所有HRQOL参数和主要冠状面Cobb角均具有统计学意义(P<0.05)。计算得出的区分手术组和非手术组的COMI、ODI、SF-36 PCS和SRS-22的最佳截断值分别为5.7、37.0、37.5和3.2(P<0.05)。所有手术患者均接受后路手术。总体而言,观察到135例并发症(71例严重,64例轻微)和1例死亡。手术治疗的患者在术后2年时,除SF-36 MCS外,所有HRQOL参数在临床和HRQOL参数方面均有改善,即使存在并发症(P<0.05),而非手术患者在2年结束时没有变化或恶化。

结论

尽管并发症发生率相对较高,但在本研究人群中,接受手术治疗的患者在临床上实现显著且相关的HRQOL改善的可能性更高。

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