Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
Key Laboratory of AIDS Immunology of the National Health and Family Planning Commission, The First Affiliated Hospital, China Medical University, Shenyang, China.
Transfusion. 2019 Nov;59(11):3431-3441. doi: 10.1111/trf.15515. Epub 2019 Sep 18.
Understanding the latest human immunodeficiency virus (HIV) epidemic in voluntary blood donors could be of great value to further increase blood safety in China, as transfusion-transmitted infection places a heavy burden on both infected individuals and the whole society. Therefore, we evaluated the national HIV prevalence of voluntary blood donors in China and characteristics of HIV-infected blood donors.
We searched literature in Chinese and English concerning the prevalence of HIV infections in Chinese voluntary blood donors from 2010 to 2017, yielding 97 eligible papers. We performed a meta-analysis to calculate pooled HIV prevalence, and characteristics of HIV-infected blood donors were also extracted.
The pooled sample consisted of 21,100,755 voluntary blood donors and 4,755 HIV-infected blood donors. Pooled HIV prevalence of China voluntary blood donors during 2010 to 2017 was 21.02 in 100,000. Pooled HIV prevalence varied in different provinces, showing greater severity in Southwest, Northwest, and South China. Subgroup analysis also showed a significantly increasing trend from 2010 to 2017. The majority of HIV-infected blood donors in China were male, young, unmarried, nonlocal residents, receiving 12 years or less of schooling, and first-time donors. Nearly 90% of HIV-infected blood donors acquired their infections through sexual contact.
The prevalence of HIV increased in China among voluntary blood donors during 2010 to 2017, highlighting the risk of HIV transmission by transfusion. Blood centers and public health services should improve screening and intervention programs targeting voluntary blood donors and expand education on blood safety in areas experiencing severe epidemics and among high-risk populations.
了解中国自愿献血者中最新的人类免疫缺陷病毒（HIV）流行情况，对于进一步提高血液安全水平具有重要意义，因为输血传播感染给感染者和整个社会带来了沉重的负担。因此，我们评估了中国自愿献血者的全国 HIV 流行率以及 HIV 感染献血者的特征。
我们检索了 2010 年至 2017 年中国自愿献血者 HIV 感染流行率的中英文文献，共纳入 97 篇合格文献。我们进行了荟萃分析以计算 HIV 流行率的合并值，并提取了 HIV 感染献血者的特征。
合并样本包括 21100755 名自愿献血者和 4755 名 HIV 感染献血者。2010 年至 2017 年中国自愿献血者的 HIV 流行率为每 10 万人 21.02。不同省份的 HIV 流行率存在差异，西南、西北和华南地区较为严重。亚组分析还显示，从 2010 年到 2017 年呈显著上升趋势。中国大多数 HIV 感染献血者为男性、年轻、未婚、非本地居民、受教育程度在 12 年或以下、初次献血者。近 90%的 HIV 感染献血者通过性接触感染。
2010 年至 2017 年，中国自愿献血者的 HIV 流行率呈上升趋势，突出了输血传播 HIV 的风险。血液中心和公共卫生服务机构应改进针对自愿献血者的筛查和干预计划，并在疫情严重地区和高危人群中加强血液安全教育。
