具有硫化氢激活近红外响应性的治疗诊断纳米平台，用于成像引导按需药物释放。
Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release.
机构信息
Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Shanghai, 201800, China.
出版信息
Angew Chem Int Ed Engl. 2019 Nov 18;58(47):16826-16830. doi: 10.1002/anie.201909883. Epub 2019 Oct 14.
NIR light responsive nanoplatforms hold great promise for on-demand drug release in precision cancer medicine. However, currently available systems utilize "always-on" photothermal transducers that lack target specificity, and thus inaccurately differentiate tumors from normal tissues. Developed here is a theranostic nanoplatform featuring H S-mediated in situ production of NIR photothermal agents for imaging-guided and photocontrolled drug release. The system targets H S-rich cancers. This nanoplatform shows H S-activatable NIR-II emission and NIR light controllable release of the drug Camptothecin-11. Upon administering the system to HCT116 tumor-bearing mice, the tumor is greatly suppressed with minimal side effects, arising from the synergy of the cancer-specific and NIR light activated therapy. This theranostic nanoplatform thus sheds light on precision medicine with guidance through NIR-II imaging.
近红外光响应纳米平台在精准癌症医学中具有按需药物释放的巨大潜力。然而，目前可用的系统利用“始终开启”的光热换能器，缺乏靶向特异性，因此无法准确地区分肿瘤与正常组织。本研究开发了一种治疗学纳米平台，其特点是 H2S 介导的近红外光热剂的原位生成，用于成像引导和光控药物释放。该系统针对富含 H2S 的癌症。该纳米平台表现出 H2S 激活的近红外二区发射和近红外光可控的喜树碱-11 的药物释放。将该系统施用于 HCT116 荷瘤小鼠后，肿瘤得到了极大的抑制，副作用极小，这是由于癌症特异性和近红外光激活治疗的协同作用。因此，这种治疗学纳米平台通过近红外二区成像指导为精准医学提供了新的思路。
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