Xie Yuting, Yang Ze, Shen Hang, Chen Jingyi, Weitz David A, Chen Dong, Sheng Jianpeng, Liang Tingbo
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Adv Sci (Weinh). 2025 Jan;12(2):e2410844. doi: 10.1002/advs.202410844. Epub 2024 Nov 21.
Chemotherapy is an effective option for cancer treatment. However, its clinical application is often limited by the severe side effects of chemical drugs. To overcome these limitations, a novel drug-loaded phase-change nanocapsule system is developed. These nanocapsules are assembled via one-step electrostatic self-assembly through guided interfacial engineering. The phase change material core nanocapsules demonstrate great photothermal-controlled drug release performance and exhibit excellent tumor-targeting drug delivery performance both in vitro and in vivo via the binding of hyaluronic acid shell on the nanocapsule surface with corresponding receptors on the tumor cell membrane. The phototherapy function of the nanocapsules enhances immune activation within the tumor microenvironment, as demonstrated by flow cytometry and multiplex immunohistochemistry. The developed nanocapsules are biocompatible, versatile, and scalable and offer a promising smart delivery platform for controllable near-infrared triggered drug release and photothermal therapy.
化疗是癌症治疗的一种有效选择。然而，其临床应用常常受到化学药物严重副作用的限制。为克服这些限制，开发了一种新型载药相变纳米胶囊系统。这些纳米胶囊通过引导界面工程的一步静电自组装进行组装。相变材料核心纳米胶囊展现出优异的光热控释药物性能，并且通过纳米胶囊表面的透明质酸壳与肿瘤细胞膜上相应受体的结合，在体外和体内均表现出出色的肿瘤靶向给药性能。纳米胶囊的光疗功能增强了肿瘤微环境内的免疫激活，这通过流式细胞术和多重免疫组织化学得以证明。所开发的纳米胶囊具有生物相容性、多功能性和可扩展性，为可控近红外触发药物释放和光热疗法提供了一个有前景的智能递送平台。
