Zhang Wansu, Deng Weixing, Zhang Hua, Sun Xiaoli, Huang Ting, Wang Wenjun, Sun Pengfei, Fan Quli, Huang Wei
Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China.
Key Lab of Optical Communication Science and Technology of Shandong Province & School of Physics Science and Information Engineering, Liaocheng University, Liaocheng, 252059, China.
Biomaterials. 2020 Jun;243:119934. doi: 10.1016/j.biomaterials.2020.119934. Epub 2020 Mar 2.
Application of 1064 nm activatable NIR-IIa fluorescence imaging (FI) and NIR-II photothermal therapy (PTT) results in high-resolution imaging and good deep-tissue therapy, respectively. Combining NIR-IIa FI with NIR-II PTT may allow precise diagnosis guided efficient treatment of deep-tissue tumors. However, designing a 1064 activatable theranostic nanoplatform using a single dye for both NIR-IIa FI and NIR-II PTT is a challenge. Herein, we synthesized squaraine-based semiconducting polymer nanoparticles (PSQPNs-DBCO) that were excited by a 1064 nm laser for precise NIR-IIa fluorescence imaging guided NIR-II PTT treatment. Combined with bioorthogonal labeling technology, the PSQPNs-DBCO largely accumulated in the tumor section, extremely enhancing signal-to-background ratio (SBR) of imaging and NIR-II PTT efficiency of tumor in live colorectal-bearing animals.
应用1064纳米可激活近红外二区a型荧光成像（FI）和近红外二区光热疗法（PTT）分别可实现高分辨率成像和良好的深部组织治疗效果。将近红外二区a型荧光成像与近红外二区光热疗法相结合，可能有助于在精确诊断的指导下对深部组织肿瘤进行有效治疗。然而，使用单一染料设计用于近红外二区a型荧光成像和近红外二区光热疗法的1064可激活诊疗纳米平台是一项挑战。在此，我们合成了基于方酸菁的半导体聚合物纳米颗粒（PSQPNs-DBCO），其可被1064纳米激光激发，用于精确的近红外二区a型荧光成像引导下的近红外二区光热疗法治疗。结合生物正交标记技术，PSQPNs-DBCO在荷瘤活体动物的肿瘤部位大量聚集，极大地提高了成像的信噪比（SBR）以及肿瘤的近红外二区光热疗法治疗效率。
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