Federal Research Institution of Maternity and Child Care, Russian Ministry of Public Health , Ekaterinburg , Russia.
Moscow State University Named after M.V. Lomonosov, The Institute of Physical, and Chemical Biology Named after A.N. Belozersky , Moscow , Russia.
Gynecol Endocrinol. 2019;35(sup1):45-48. doi: 10.1080/09513590.2019.1653562.
The scanning electron microscopy of the endometrial surface epithelium during the 'implantation window' was performed in 119 patients with uterine factor of infertility or recurrent miscarriage due to endometrial hypoplasia. Ultramorphological picture of the surface endometrial epithelium was characterized by aplasia and hypoplasia of pinopodes (67.39%), dense cell - cell contacts (69.53%), heteromorphy of secretory cells (15.22%) in combination with atypia of microenvironment cells (50%) in patients with infertility. The asynchronous development of pinopodes (46.67%) and the absence of intercellular contacts separation during the 'implantation window' (84.44%) was observed in patients with recurrent miscarriage. The revealed disturbance determines the mechanisms of the blastocyst adhesion violation and trophoblast invasion in the different stages of implantation in patients with uterine factor of infertility and recurrent miscarriage.
对 119 例因子宫内膜发育不良导致子宫因素不孕或反复流产的患者的“着床窗口”期间的子宫内膜表面上皮进行了扫描电子显微镜检查。表面子宫内膜上皮的超微形态特征为：无指状突起（67.39%）、细胞-细胞紧密接触（69.53%）、分泌细胞异型性（15.22%），结合不孕患者的微环境细胞异型性（50%）。在反复流产患者中，观察到指状突起发育不同步（46.67%）和“着床窗口”期间细胞间接触分离缺失（84.44%）。所揭示的紊乱决定了在植入的不同阶段，胚胎着床因子不孕和反复流产患者中，胚泡黏附破坏和滋养细胞浸润的机制。
