Runco Daniel V, Yoon Lisa, Grooss Samantha A, Wong Christopher K
Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA.
Emory University School of Medicine, Department of Pediatrics, Division of Pediatric Hematology/Oncology/BMT, Atlanta, GA.
J Natl Cancer Inst Monogr. 2019 Sep 1;2019(54):163-168. doi: 10.1093/jncimonographs/lgz025.
Brain tumors have been the most common pediatric solid tumor and leading cause of morbidity and mortality. Improved survival emphasizes the importance of adverse treatment effects especially related to nutrition and exercise. Although studies have examined nutrition and exercise outcomes, few randomized trials exist. This narrative review included a systematic literature search with analysis of controlled or single group studies examining clinical and quality-of-life impact of nutrition or exercise interventions. Seven articles were included. Three nutrition studies demonstrated improvement with proactive feeding tubes, nutritional supplementation, and nutritional status. Two exercise studies showed improvement in measures of fitness and neuroanatomy with exercise in pediatric brain tumor survivors; two cohort studies demonstrated a link between quality of life and physical activity. Preliminary studies show nutrition and exercise may improve physical well-being and quality of life, suggesting future controlled studies are warranted to inform clinical care of children with brain tumors.
脑肿瘤一直是最常见的儿科实体瘤，也是发病和死亡的主要原因。生存率的提高凸显了不良治疗效果的重要性，尤其是与营养和运动相关的效果。尽管已有研究探讨了营养和运动的结果，但随机试验却很少。本叙述性综述包括一项系统的文献检索，分析了对照研究或单组研究，以考察营养或运动干预对临床和生活质量的影响。共纳入7篇文章。三项营养研究表明，采用主动饲管、营养补充和营养状况改善措施可取得良好效果。两项运动研究显示，儿科脑肿瘤幸存者通过运动，其体能和神经解剖学指标有所改善；两项队列研究表明生活质量与身体活动之间存在关联。初步研究表明，营养和运动可能改善身体健康和生活质量，这表明未来有必要开展对照研究，为脑肿瘤患儿的临床护理提供依据。
