Serviço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.
Parasite Immunol. 2019 Dec;41(12):e12671. doi: 10.1111/pim.12671. Epub 2019 Oct 8.
Schistosomiasis affects about 240 million people worldwide and is estimated that about 700 million people live in areas at risk of infection. In the context of immune response associated with infection by Schistosoma mansoni, the role of memory T cells is not well understood.
To evaluate the frequency of memory CD4 and CD8 T cells from individuals resistant and susceptible to Schistosoma mansoni infection.
We selected individuals with low (resistant) and high (susceptible) parasite burden using databases generated during previous studies carried out in the same endemic area. The cell surface markers were performed using flow cytometry. In this study, the resistant individuals showed an increase in the CD4 memory T-cell pool associated with an increase in the central memory cell (TCM) and a decrease in the effector memory cell (T ). Individuals susceptible to infection had higher frequencies of effector memory cells compared to resistant individuals.
These data suggest that resistance to S mansoni infection may be associated with an increase in the number of CD4 memory T cells and susceptibility to infection is associated with a decrease in the central memory cell as well as high proportions of effector memory cells.
血吸虫病影响全球约 2.4 亿人，据估计，约有 7 亿人生活在有感染风险的地区。在与曼氏血吸虫感染相关的免疫反应背景下，记忆 T 细胞的作用尚不清楚。
评估对曼氏血吸虫感染具有抗性和易感性的个体中记忆 CD4 和 CD8 T 细胞的频率。
我们使用在同一流行地区进行的先前研究中生成的数据库，选择了寄生虫负担低（抗性）和高（易感性）的个体。使用流式细胞术进行细胞表面标记。在这项研究中，抗性个体显示与中央记忆细胞（TCM）增加和效应记忆细胞（TEM）减少相关的 CD4 记忆 T 细胞池增加。与抗性个体相比，易感染的个体具有更高频率的效应记忆细胞。
这些数据表明，对 S mansoni 感染的抗性可能与 CD4 记忆 T 细胞数量的增加有关，而感染的易感性与中央记忆细胞的减少以及效应记忆细胞的高比例有关。
