Watanabe Kanji, Mwinzi Pauline N M, Black Carla L, Muok Erick M O, Karanja Diana M S, Secor W Evan, Colley Daniel G
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602-3799, USA.
Am J Trop Med Hyg. 2007 Oct;77(4):676-82.
Schistosomiasis mansoni is usually a chronic infection that leads to long-term, systemic exposure to schistosome antigens. Experimental Schistosoma mansoni infection is associated with immunoregulatory mechanisms, including T regulatory cells (Treg) that may help control morbidity and dampen resistance to re-infection. We now show that some schistosomiasis mansoni patients have high proportions of CD3(+)/CD4(+)/CD25(high) Treg. On effective treatment with praziquantel, these high Treg percentages decrease, and fewer of the remaining Treg express CD45RO. The proportion of Treg in S. mansoni-infected patients is inversely related to their percentage of activated, putative effector T cells (CD3(+)/CD4(+)/CD25(medium)/HLA-DR(+) cells). We conclude some, but not all, schistosomiasis mansoni patients develop high percentages of circulating Treg, and effective treatment both decreases the levels of these cells and changes their phenotypes, possibly because of the removal of constant exposure to antigens from intravascular, egg-producing adult worms.
曼氏血吸虫病通常是一种慢性感染，会导致长期、全身性接触血吸虫抗原。实验性曼氏血吸虫感染与免疫调节机制有关，包括可能有助于控制发病并减弱对再感染抵抗力的调节性T细胞（Treg）。我们现在发现，一些曼氏血吸虫病患者具有高比例的CD3(+)/CD4(+)/CD25(高表达) Treg。在用吡喹酮进行有效治疗后，这些高Treg百分比会降低，并且剩余的Treg中表达CD45RO的数量减少。曼氏血吸虫感染患者中Treg的比例与活化的、假定的效应T细胞（CD3(+)/CD4(+)/CD25(中等)/HLA-DR(+)细胞）的百分比呈负相关。我们得出结论，部分但并非所有曼氏血吸虫病患者会出现高比例的循环Treg，有效治疗既能降低这些细胞的水平，又能改变其表型，这可能是因为消除了来自血管内产卵成虫的持续抗原暴露。
