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Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages.肠道微生物群衍生的色氨酸代谢产物调节肝细胞和巨噬细胞中的炎症反应。
Cell Rep. 2019 Sep 17;28(12):3285. doi: 10.1016/j.celrep.2019.08.080.
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Indoles - Gut Bacteria Metabolites of Tryptophan with Pharmacotherapeutic Potential.吲哚——色氨酸的肠道细菌代谢产物,具有药物治疗潜力。
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Beneficial actions of microbiota-derived tryptophan metabolites.微生物衍生色氨酸代谢物的有益作用。
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Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytes.合成的烯酮脂肪酸类似于肠道微生物群的代谢物,可抑制脂肪细胞中巨噬细胞介导的炎症。
Mol Nutr Food Res. 2017 Oct;61(10). doi: 10.1002/mnfr.201700064. Epub 2017 Jul 19.
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Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials.人类肠道微生物群代谢在传统使用的富含鞣花单宁的植物材料抗炎作用中的作用。
J Ethnopharmacol. 2014 Aug 8;155(1):801-9. doi: 10.1016/j.jep.2014.06.032. Epub 2014 Jun 23.
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Serotonin, tryptophan metabolism and the brain-gut-microbiome axis.血清素、色氨酸代谢与脑-肠-微生物群轴
Behav Brain Res. 2015 Jan 15;277:32-48. doi: 10.1016/j.bbr.2014.07.027. Epub 2014 Jul 29.
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Caspase recruitment domain 9, microbiota, and tryptophan metabolism: dangerous liaisons in inflammatory bowel diseases.半胱天冬酶募集结构域9、微生物群与色氨酸代谢:炎症性肠病中的危险关联
Curr Opin Clin Nutr Metab Care. 2017 Jul;20(4):243-247. doi: 10.1097/MCO.0000000000000382.
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Kynurenine pathway metabolism and the microbiota-gut-brain axis.犬尿氨酸途径代谢与微生物群-肠-脑轴
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Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction.HIV 和 2 型糖尿病对肠道微生物多样性、色氨酸代谢和血管内皮功能障碍的影响。
Sci Rep. 2018 Apr 30;8(1):6725. doi: 10.1038/s41598-018-25168-3.
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Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages.尿石素是鞣花单宁的肠道微生物衍生代谢产物,可抑制脂多糖诱导的RAW 264.7小鼠巨噬细胞炎症反应。
Mol Nutr Food Res. 2015 Nov;59(11):2168-77. doi: 10.1002/mnfr.201500264. Epub 2015 Aug 27.

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Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in a hamster model of COVID-19.整合宏基因组学和代谢组学揭示了新冠病毒感染仓鼠模型中与年龄相关的肠道微生物群和代谢物变化。
Gut Microbes. 2025 Dec;17(1):2486511. doi: 10.1080/19490976.2025.2486511. Epub 2025 Apr 2.
2
Circulating Interleukin-22 Is a Biomarker for Newly Diagnosed Type 2 Diabetes Mellitus and Associated with Hypoglycemic Effect of Sitagliptin.循环白细胞介素-22是新诊断2型糖尿病的生物标志物,并与西他列汀的降糖作用相关。
Diabetes Metab Syndr Obes. 2025 Mar 3;18:703-713. doi: 10.2147/DMSO.S509866. eCollection 2025.
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The Metabolite Indole-3-Acetic Acid of Bacteroides Ovatus Improves Atherosclerosis by Restoring the Polarisation Balance of M1/M2 Macrophages and Inhibiting Inflammation.卵形拟杆菌的代谢产物吲哚-3-乙酸通过恢复M1/M2巨噬细胞的极化平衡和抑制炎症来改善动脉粥样硬化。
Adv Sci (Weinh). 2025 Mar;12(11):e2413010. doi: 10.1002/advs.202413010. Epub 2025 Jan 22.
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Serum metabolic alterations in chickens upon infectious bursal disease virus infection.传染性法氏囊病病毒感染后鸡血清的代谢变化
BMC Vet Res. 2024 Dec 19;20(1):569. doi: 10.1186/s12917-024-04402-3.
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Ruminococcus gnavus in the gut: driver, contributor, or innocent bystander in steatotic liver disease?肠道中的迟缓瘤胃球菌:脂肪性肝病的驱动因素、促成因素还是无辜旁观者?
FEBS J. 2025 Mar;292(6):1252-1264. doi: 10.1111/febs.17327. Epub 2024 Nov 26.
6
Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation.肠道微生物代谢产物吲哚-3-乙酸通过黏蛋白硫酸盐化维持肠道上皮细胞稳态。
Gut Microbes. 2024 Jan-Dec;16(1):2377576. doi: 10.1080/19490976.2024.2377576. Epub 2024 Jul 27.
7
Cinnamic Acid, Perillic Acid, and Tryptophan Metabolites Differentially Regulate Ion Transport and Serotonin Metabolism and Signaling in the Mouse Ileum In Vitro.肉桂酸、紫苏酸和色氨酸代谢物在体外对小鼠回肠的离子转运和 5-羟色胺代谢及信号转导的调控作用存在差异。
Int J Mol Sci. 2024 Jun 18;25(12):6694. doi: 10.3390/ijms25126694.
8
Indoor metabolites and chemicals outperform microbiome in classifying childhood asthma and allergic rhinitis.在儿童哮喘和过敏性鼻炎的分类中,室内代谢物和化学物质比微生物组表现更优。
Eco Environ Health. 2023 Aug 22;2(4):208-218. doi: 10.1016/j.eehl.2023.08.001. eCollection 2023 Dec.
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Current insights into the interplay between gut microbiota-derived metabolites and metabolic-associated fatty liver disease.目前对肠道微生物群衍生代谢产物与代谢相关脂肪性肝病之间相互作用的见解。
Tzu Chi Med J. 2023 Sep 7;35(4):290-299. doi: 10.4103/tcmj.tcmj_122_23. eCollection 2023 Oct-Dec.
10
Essential Amino Acid Metabolites as Chemical Mediators of Host-Microbe Interaction in the Gut.必需氨基酸代谢物作为肠道中宿主-微生物相互作用的化学介质。
Annu Rev Microbiol. 2023 Sep 15;77:479-497. doi: 10.1146/annurev-micro-032421-111819. Epub 2023 Jun 20.

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages.

作者信息

Krishnan Smitha, Ding Yufang, Saeidi Nima, Choi Maria, Sridharan Gautham V, Sherr David H, Yarmush Martin L, Alaniz Robert C, Jayaraman Arul, Lee Kyongbum

出版信息

Cell Rep. 2019 Sep 17;28(12):3285. doi: 10.1016/j.celrep.2019.08.080.

DOI:10.1016/j.celrep.2019.08.080
PMID:31533048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6935324/
Abstract
摘要