Mochizuki Kanako, Kondo Yukio, Hosokawa Kohei, Ohata Kinya, Yamazaki Hirohito, Takami Akiyoshi, Sasaki Motoko, Sato Yasunori, Nakanuma Yasuni, Nakao Shinji
Department of Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Japan.
Intern Med. 2014;53(5):499-503. doi: 10.2169/internalmedicine.53.1192.
Adenoviruses are increasingly recognized as important pathogens following allogeneic stem cell transplantation. We herein report two cases of disseminated adenovirus infection that presented with nodular shadows on chest X-ray after allogeneic bone marrow transplantation from unrelated donors. Both patients died of respiratory failure. Autopsies revealed adenovirus infection of multiple organs. Adenovirus infection should be suspected when nodular lung lesions of unknown origin appear in allogeneic stem cell transplant recipients.
腺病毒越来越被认为是异基因干细胞移植后的重要病原体。我们在此报告两例播散性腺病毒感染病例，这两例患者在接受来自无关供体的异基因骨髓移植后，胸部X线片上出现结节状阴影。两名患者均死于呼吸衰竭。尸检显示多个器官存在腺病毒感染。当异基因干细胞移植受者出现不明原因的肺部结节性病变时，应怀疑腺病毒感染。
