Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Viruses. 2023 Jan 5;15(1):161. doi: 10.3390/v15010161.
Human adenovirus (HAdV) is extremely common and can rapidly spread in confined populations such as daycare centers, hospitals, and retirement homes. Although HAdV usually causes only minor illness in otherwise healthy patients, HAdV can cause significant morbidity and mortality in certain populations, such as the very young, very old, or immunocompromised individuals. During infection, the viral DNA undergoes dramatic changes in nucleoprotein structure that promote the rapid expression of viral genes, replication of the DNA, and generation of thousands of new infectious virions-each process requiring a distinct complement of virus and host-encoded proteins. In this review, we summarize our current understanding of the nucleoprotein structure of HAdV DNA during the various phases of infection, the cellular proteins implicated in mediating these changes, and the role of epigenetics in HAdV gene expression and replication.
人腺病毒（HAdV）极为常见，可在日托中心、医院和养老院等密闭人群中迅速传播。尽管 HAdV 通常只会导致健康状况良好的患者出现轻微疾病，但 HAdV 可导致某些人群（如非常年幼、非常年老或免疫功能低下的个体）出现显著发病率和死亡率。在感染过程中，病毒 DNA 的核蛋白结构会发生剧烈变化，从而促进病毒基因的快速表达、DNA 的复制和数千个新的传染性病毒粒子的产生——每个过程都需要独特的病毒和宿主编码蛋白的组合。在这篇综述中，我们总结了我们目前对感染各阶段 HAdV DNA 核蛋白结构、涉及这些变化的细胞蛋白以及表观遗传学在 HAdV 基因表达和复制中的作用的理解。
