Kim Min Jhi, Kim Daham, Koo Ja Seung, Lee Ju Hee, Nam Kee-Hyun
Department of Surgery, CHA Ilsan Medical Center, 65470CHA University School of Medicine, Goyang-si, Gyeonggi-do, South Korea.
Department of Surgery, Graduate School, 37991Yonsei University College of Medicine, Seoul, South Korea.
Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221089933. doi: 10.1177/15330338221089933.
This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. This prospective cohort study comprised patients with thyroid tumors who visited our hospital, from 2017 to 2018. The level of vitamin D receptor expression from thyroid tissue was measured in patients with thyroid tumor and evaluated for correlation with serum vitamin D levels and clinicopathologic characteristics of papillary thyroid cancer. Data from 501 patients with papillary thyroid cancer from The Cancer Genome Atlas database were analyzed. Increased vitamin D receptor protein and mRNA expression were observed in papillary thyroid cancer compared to those in normal and benign tissues. Lower vitamin D receptor protein expression was associated with high TNM stage papillary thyroid cancer and low p21 protein expression. Lower relative vitamin D receptor mRNA expression in papillary thyroid cancer was associated with low serum 25-hydroxyvitamin D level. The Cancer Genome Atlas database showed a positive correlation among mRNA expression of vitamin D receptor, CYP24A1, and p21. An association between decreased vitamin D receptor protein expression and advanced stage papillary thyroid cancer, and a correlation between low vitamin D receptor mRNA expression with low serum 25-hydroxyvitamin D level was observed. Low vitamin D receptor expression in papillary thyroid cancer was shown to positively correlate with low serum vitamin D level and disease aggressiveness.
本研究旨在评估维生素D受体（维生素D信号通路中的一个重要组成部分）与血清维生素D之间的关联及其在甲状腺乳头状癌中的临床意义。这项前瞻性队列研究纳入了2017年至2018年期间到我院就诊的甲状腺肿瘤患者。对甲状腺肿瘤患者甲状腺组织中的维生素D受体表达水平进行检测，并评估其与血清维生素D水平及甲状腺乳头状癌临床病理特征的相关性。分析了来自癌症基因组图谱数据库的501例甲状腺乳头状癌患者的数据。与正常组织和良性组织相比，甲状腺乳头状癌中维生素D受体蛋白和mRNA表达增加。较低的维生素D受体蛋白表达与高TNM分期的甲状腺乳头状癌及低p21蛋白表达相关。甲状腺乳头状癌中较低的维生素D受体相对mRNA表达与低血清25-羟基维生素D水平相关。癌症基因组图谱数据库显示维生素D受体、CYP24A1和p21的mRNA表达之间呈正相关。观察到维生素D受体蛋白表达降低与晚期甲状腺乳头状癌之间存在关联，以及低维生素D受体mRNA表达与低血清25-羟基维生素D水平之间存在相关性。甲状腺乳头状癌中低维生素D受体表达与低血清维生素D水平和疾病侵袭性呈正相关。
