Department of Chemistry , New York University , 100 Washington Square East , New York , New York 10003 , United States.
Org Lett. 2019 Oct 4;21(19):7763-7767. doi: 10.1021/acs.orglett.9b02708. Epub 2019 Sep 19.
Macrocyclic hosts have long been the workhorses of molecular recognition. Despite the widespread use of container-shaped molecules as synthetic receptors, an efficient preparation of cavitands bearing multiple functional groups has not been realized. This Letter describes a new cavitand derived from a sequence-defined oligoamide foldamer scaffold. A solid-phase synthesis approach is reported, which enables the display of multiple chemically diverse functional groups on the cavitand rim.
大环主体一直是分子识别的主力军。尽管将容器形状的分子用作合成受体已得到广泛应用，但尚未实现具有多个官能团的空腔分子的有效制备。本文描述了一种新的空腔分子，它源自序列确定的寡肽折叠骨架。报道了一种固相合成方法，该方法能够在空腔分子边缘展示多种化学性质不同的官能团。
