Department of Chemistry , New York University , New York , New York 10003 , United States.
Org Lett. 2018 Jul 6;20(13):3879-3882. doi: 10.1021/acs.orglett.8b01463. Epub 2018 Jun 13.
The design and characterization of a proteomimetic foldamer that displays lateral flexibility endowed by intramolecular bifurcated hydrogen bonds is reported. The MAMBA scaffold, derived from meta-aminomethylbenzoic acid, adopts a serpentine conformation that mimics the side chain projection of all four residues in a β-hairpin turn.
报道了一种具有分子内分叉氢键赋予的横向柔性的拟肽折叠体的设计和特性。MAMBA 支架来源于间氨基甲基苯甲酸,采用蛇形构象,模拟 β-发夹转角中所有四个残基的侧链投影。