Fachbereich Chemie-Organische Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Str. 54, 67663 Kaiserslautern, Germany.
Molecules. 2022 Apr 28;27(9):2821. doi: 10.3390/molecules27092821.
Work on the use of cyclic peptides or pseudopeptides as synthetic receptors started even before the field of supramolecular chemistry was firmly established. Research initially focused on the development of synthetic ionophores and involved the use of macrocycles with a repeating sequence of subunits along the ring to facilitate the correlation between structure, conformation, and binding properties. Later, nonnatural amino acids as building blocks were also considered. With growing research in this area, cyclopeptides and related macrocycles developed into an important and structurally diverse receptor family. This review provides an overview of these developments, starting from the early years. The presented systems are classified according to characteristic structural elements present along the ring. Wherever possible, structural aspects are correlated with binding properties to illustrate how natural or nonnatural amino acids affect binding properties.
对环状肽或拟肽作为合成受体的研究早在超分子化学领域确立之前就已经开始了。研究最初集中在合成离子载体的开发上，涉及使用具有沿环重复亚基序列的大环来促进结构、构象和结合特性之间的相关性。后来，也考虑了作为构建块的非天然氨基酸。随着该领域研究的不断深入，环肽和相关的大环发展成为一个重要的、结构多样的受体家族。这篇综述从早期开始概述了这些发展。所呈现的系统根据环上存在的特征结构元件进行分类。只要有可能，就将结构方面与结合特性相关联，以说明天然或非天然氨基酸如何影响结合特性。
