Enechukwu Chukwunonso Isaiah, Onuegbu Anaelechi Jude, Olisekodiaka Madu Japheth, Eleje George Uchenna, Ikechebelu Joseph Ifeanyichukwu, Ugboaja Joseph Odirichukwu, Amah Ubuo Kalu, Okwara John Ekenedirichukwu, Igwegbe Anthony Osita
Department of Obstetrics & Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria, Nigeria.
Department of Chemical Pathology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria.
Obstet Gynecol Sci. 2019 Sep;62(5):335-343. doi: 10.5468/ogs.2019.62.5.335. Epub 2019 Aug 6.
To determine the activities of oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome (PCOS) in Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria.
This was a nested case-control study consisting of 50 PCOS patients and 50 healthy women of the same age range without any evidence of PCOS. The study measured the levels of malondialdehyde (MDA), activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (TAC); concentrations of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), as well as high-density lipoprotein cholesterol (HDL-C) using standard spectrophotometric methods. Anthropometric indices were also assessed. -values of <0.05 were taken to be statistically significant.
There were significantly higher levels of MDA (=0.002), lower activity of SOD (<0.001), and lower TAC (=0.001) in PCOS patients when compared with the controls. There were higher concentrations of TC (=0.017) and LDL-C =0.012) in PCOS patients than in controls. Significant differences were not observed between the 2 groups in terms of the activity of GSH-Px, as well as the concentrations of HDL-C and TG. The body mass index, waist circumference, and waist-hip ratio were all significantly higher in PCOS patients.
This study revealed higher levels of MDA, as well as lower activity of SOD and TAC, among PCOS patients. Furthermore, there were higher levels of TC and LDL-C among the PCOS patients. Hence, monitoring these parameters may improve the clinical management of PCOS.
确定尼日利亚纳姆迪·阿齐克韦大学教学医院纽维分院多囊卵巢综合征（PCOS）患者氧化应激标志物活性和血脂情况。
这是一项巢式病例对照研究，包括50例PCOS患者和50例年龄范围相同且无PCOS证据的健康女性。该研究采用标准分光光度法测量丙二醛（MDA）水平、超氧化物歧化酶（SOD）活性、谷胱甘肽过氧化物酶（GSH-Px）活性、总抗氧化能力（TAC）；总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）以及高密度脂蛋白胆固醇（HDL-C）的浓度。还评估了人体测量指标。P<0.05被认为具有统计学意义。
与对照组相比，PCOS患者的MDA水平显著更高（P=0.002），SOD活性更低（P<0.001），TAC更低（P=0.001）。PCOS患者的TC浓度（P=0.017）和LDL-C浓度（P=0.012）高于对照组。两组在GSH-Px活性、HDL-C和TG浓度方面未观察到显著差异。PCOS患者的体重指数、腰围和腰臀比均显著更高。
本研究显示PCOS患者中MDA水平更高，SOD和TAC活性更低。此外，PCOS患者中TC和LDL-C水平更高。因此，监测这些参数可能会改善PCOS的临床管理。
