Department of Obstetrics and Gynecology, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA.
Fertil Steril. 2011 Mar 1;95(3):1073-9.e1-11. doi: 10.1016/j.fertnstert.2010.12.027. Epub 2011 Jan 17.
To quantify the magnitude and pattern of low-density lipoprotein (LDL) cholesterol and nonhigh-density lipoprotein (HDL) cholesterol levels in women with polycystic ovary syndrome (PCOS) versus control women.
Systematic review and meta-analysis of lipid levels in published cross-sectional studies worldwide where PCOS women and controls were examined and sampled.
MAIN OUTCOME MEASURE(S): Differences in plasma lipids (including triglycerides, HDL-cholesterol, LDL-cholesterol, and nonHDL-cholesterol) in PCOS versus control subjects were calculated. Comparisons were made with and without body mass index (BMI) matching.
RESULT(S): Triglyceride levels were 26 mg/dL (95% confidence interval [CI] 17-35) higher and HDL-cholesterol concentrations 6 mg/dL (95% CI 4-9) lower in women with PCOS. Also, LDL-cholesterol and nonHDL-cholesterol concentrations were higher in PCOS: by 12 mg/dL (95% CI 10-16) and 19 mg/dL (95% CI 16-22), respectively. With BMI matching, LDL-cholesterol and nonHDL-cholesterol were still higher in PCOS: by 9 mg/dL (95% CI 6-12) and 16 mg/dL (95% CI 14-19), respectively. LDL-cholesterol and nonHDL-cholesterol differences were greater with National Institutes of Health criteria [15 mg/dL (95% CI 13-17) and 21 mg/dL (95% CI 16-25), respectively] versus Rotterdam criteria [8 mg/dL (95% CI 5-12) and 17 (95% CI 13-22), respectively].
CONCLUSION(S): Dyslipidemia is common in PCOS. Beyond known alterations in triglycerides and HDL-cholesterol, women with PCOS have higher LDL-cholesterol and nonHDL-cholesterol, regardless of BMI. We recommend that all women with PCOS be screened for dyslipidemia, including LDL-cholesterol and nonHDL-cholesterol determinations, for effective cardiovascular risk prevention.
定量比较多囊卵巢综合征（PCOS）女性与对照女性的低密度脂蛋白（LDL）胆固醇和非高密度脂蛋白（HDL）胆固醇水平的幅度和模式。
对全球已发表的横断面研究进行系统评价和荟萃分析，这些研究对 PCOS 女性和对照女性进行了检查和抽样。
主要观察指标（s）：计算 PCOS 与对照受试者之间血浆脂质（包括甘油三酯、HDL-胆固醇、LDL-胆固醇和非 HDL-胆固醇）的差异。比较有无体重指数（BMI）匹配。
PCOS 女性的甘油三酯水平高 26mg/dL（95%置信区间[CI] 17-35），HDL-胆固醇浓度低 6mg/dL（95%CI 4-9）。此外，LDL-胆固醇和非 HDL-胆固醇浓度在 PCOS 中更高：分别高 12mg/dL（95%CI 10-16）和 19mg/dL（95%CI 16-22）。BMI 匹配后，PCOS 中 LDL-胆固醇和非 HDL-胆固醇仍较高：分别高 9mg/dL（95%CI 6-12）和 16mg/dL（95%CI 14-19）。根据美国国立卫生研究院标准[分别为 15mg/dL（95%CI 13-17）和 21mg/dL（95%CI 16-25）]，而非 Rotterdam 标准[分别为 8mg/dL（95%CI 5-12）和 17mg/dL（95%CI 13-22）]，LDL-胆固醇和非 HDL-胆固醇差异更大。
血脂异常在 PCOS 中很常见。除了甘油三酯和 HDL-胆固醇的已知改变外，PCOS 女性的 LDL-胆固醇和非 HDL-胆固醇水平更高，无论 BMI 如何。我们建议所有 PCOS 女性都应进行血脂异常筛查，包括 LDL-胆固醇和非 HDL-胆固醇测定，以有效预防心血管疾病风险。
