Tang Qiuqin, Pan Feng, Wu Xian, Nichols Cody E, Wang Xinru, Xia Yankai, London Stephanie J, Wu Wei
Department of Obstetrics, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People's Republic of China.
Department of Urology, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People's Republic of China.
Environ Epidemiol. 2019 Aug 13;3(4):e055. doi: 10.1097/EE9.0000000000000055. eCollection 2019 Aug.
Numerous health effects of smoking are well-known; associations with semen quality are uncertain. Most previous studies did not adjust for potential confounders and had limited information on age at smoking initiation or smoking cessation.
We investigated 1,631 healthy fertile men in the Nanjing Medical University Longitudinal Investigation of Fertility and the Environment (NMU-LIFE) study. Relationships were examined using multivariable linear regression controlling for potential covariates.
We found a significant decrease in semen volume ( = -0.10, = 0.001) and total sperm count ( = -0.42, = 0.037), and significant increase in total motility ( = 6.02, = 0.037) and progressive motility ( = 5.52, = 0.037) in ever smokers of pack-years ≥10 compared with never smokers. We observed an inverse dose-dependent relation between smoking pack-years and semen volume ( < 0.001) and total sperm count ( = 0.010) and a positive dose-dependent relation between smoking pack-years and both total motility and progressive motility ( = 0.042 and 0.048, respectively). No significant differences in semen quality were detected among ever smokers with different ages at smoking initiation nor in former smokers compared with never smokers.
Cigarette smoking was associated with lower semen volume and total sperm count and higher sperm motility. Smoking cessation might have a restorative effect on semen quality. This finding has important implications for public health research and for understanding the development of abnormal semen quality.
吸烟对健康的诸多影响已广为人知；但其与精液质量的关联尚不确定。此前的大多数研究未对潜在混杂因素进行校正，且关于开始吸烟或戒烟时的年龄信息有限。
我们在南京医科大学生育与环境纵向研究（NMU-LIFE）中调查了1631名健康的可育男性。使用多变量线性回归控制潜在协变量来检验相关性。
我们发现，与从不吸烟者相比，吸烟史≥10包年的曾经吸烟者精液量显著减少（β = -0.10，P = 0.001）、总精子数显著减少（β = -0.42，P = 0.037），而总活力显著增加（β = 6.02，P = 0.037）、前向运动精子活力显著增加（β = 5.52，P = 0.037）。我们观察到吸烟包年数与精液量（P < 0.001）和总精子数（P = 0.010）之间呈负剂量依赖关系，与总活力和前向运动精子活力之间呈正剂量依赖关系（分别为P = 0.042和0.048）。在不同开始吸烟年龄的曾经吸烟者之间以及与从不吸烟者相比的既往吸烟者中，未检测到精液质量的显著差异。
吸烟与较低的精液量、总精子数以及较高的精子活力相关。戒烟可能对精液质量有恢复作用。这一发现对公共卫生研究以及理解异常精液质量的发展具有重要意义。
