Unit of Models for Ecotoxicology and Toxicology (METO), INERIS, 60550 Verneuil en Halatte, France; UMR-I 02 SEBIO, INERIS, Parc ALATA, BP2, 60550 Verneuil-en-Halatte, France.
UMR-I 02 SEBIO, INERIS, Parc ALATA, BP2, 60550 Verneuil-en-Halatte, France.
Sci Total Environ. 2019 Nov 20;692:854-867. doi: 10.1016/j.scitotenv.2019.07.274. Epub 2019 Jul 20.
Bisphenol A (BPA), a well-known endocrine-disrupting chemical, is ubiquitously present in the aquatic environment. Its impacts at the population level on three-spined sticklebacks (Gasterosteus aculeatus) have been studied in artificial streams with low-dose BPA concentrations. The causes explaining the observed effects remained unclear. Here, we used an individual-based model coupled to a Dynamic Energy Budget model to (i) assess the potential of modelling to predict impacts at the population level using individual level laboratory ecotoxicological endpoints and (ii) provide insight on the mechanisms of BPA toxicity in these mesocosms. To do that, both direct and indirect effects of BPA on three-spined sticklebacks were incorporated in the model. Indeed, direct BPA effects on fish have been identified based on literature data whereas indirect effects on sticklebacks have been taken into account using sampling data of their prey from the exposed artificial streams. Results of the modelling showed that direct BPA effects on fish (impacts on gonad formation, growth, male reproductive behavior, eggs and larvae survival) mainly explained the three-spined stickleback population structure in the mesocosms, but indirect effects were not negligible. Hence, this study showed the potential of modelling in risk assessment to predict the impacts on fish population viability from behavioral and physiological effects measured on organisms.
双酚 A（BPA）是一种众所周知的内分泌干扰化学物质，广泛存在于水生态环境中。在低剂量 BPA 浓度的人工溪流中，已经研究了其对三刺鱼（Gasterosteus aculeatus）种群水平的影响。但导致这些观察到的影响的原因仍不清楚。在这里，我们使用基于个体的模型与动态能量预算模型相结合，（i）评估使用个体水平的实验室生态毒理学终点预测种群水平影响的建模潜力，以及（ii）深入了解这些中观系统中 BPA 毒性的机制。为此，模型中纳入了 BPA 对三刺鱼的直接和间接影响。实际上，根据文献数据确定了 BPA 对鱼类的直接影响，而使用暴露于人工溪流中的其猎物的采样数据来考虑 BPA 对刺鱼的间接影响。模型的结果表明，BPA 对鱼类的直接影响（对性腺形成、生长、雄性生殖行为、卵子和幼虫存活率的影响）主要解释了中观系统中三刺鱼的种群结构，但间接影响不可忽视。因此，这项研究表明了建模在风险评估中的潜力，可以预测从生物体上测量的行为和生理效应对鱼类种群生存力的影响。
