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燕麦源阿魏酰基奎宁酸衍生物的抗癌概况。

Overview of the Anticancer Profile of Avenanthramides from Oat.

机构信息

Department for Life Quality Studies, Alma Mater Studiorum-Università di Bologna, Corso d'Augusto 237, 47921 Rimini, Italy.

出版信息

Int J Mol Sci. 2019 Sep 13;20(18):4536. doi: 10.3390/ijms20184536.

DOI:10.3390/ijms20184536
PMID:31540249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6770293/
Abstract

Cancer represents one of the leading causes of death worldwide. Progresses in treatment of cancer have continued at a rapid pace. However, undesirable side effects and drug resistance remain major challenges for therapeutic success. Natural products represent a valuable starting point to develop new anticancer strategies. Polyphenols, well-known as antioxidant, exert anticancer effects through the modulation of multiple pathways and mechanisms. Oat ( L., ) is a unique source of avenanthramides (AVAs), a group of polyphenolic alkaloids, considered as its signature compounds. The present review aims to offer a comprehensive and critical perspective on the chemopreventive and chemotherapeutic potential of AVAs. AVAs prevent cancer mainly by blocking reactive species. Moreover, they exhibit potential therapeutic activity through the modulation of different pathways including the activation of apoptosis and senescence, the block of cell proliferation, and the inhibition of epithelial mesenchymal transition and metastatization. AVAs are promising chemopreventive and anticancer phytochemicals, which need further clinical trials and toxicological studies to define their efficacy in preventing and reducing the burden of cancer diseases.

摘要

癌症是全球主要死因之一。癌症治疗的进展一直在迅速推进。然而，不良副作用和耐药性仍然是治疗成功的主要挑战。天然产物是开发新抗癌策略的有价值起点。多酚作为抗氧化剂，通过调节多种途径和机制发挥抗癌作用。燕麦（）是燕麦酰胺（AVAs）的独特来源，AVAs 是一组多酚类生物碱，被认为是其标志性化合物。本综述旨在对 AVA 的化学预防和化疗潜力提供全面和批判性的观点。AVAs 主要通过阻断活性物质来预防癌症。此外，它们通过调节不同的途径发挥潜在的治疗活性，包括激活细胞凋亡和衰老、阻止细胞增殖以及抑制上皮间质转化和转移。AVAs 是很有前途的化学预防和抗癌植物化学物质，需要进一步的临床试验和毒理学研究来确定它们在预防和减轻癌症疾病负担方面的功效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/565e/6770293/92aedfddd66f/ijms-20-04536-g006.jpg
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