UNC_NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
UNC Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, Chapel Hill, NC, USA.
Nat Commun. 2019 Sep 20;10(1):4324. doi: 10.1038/s41467-019-12141-5.
Here we report an ultra-long-acting tunable, biodegradable, and removable polymer-based delivery system that offers sustained drug delivery for up to one year for HIV treatment or prophylaxis. This robust formulation offers the ability to integrate multiple drugs in a single injection, which is particularly important to address the potential for drug resistance with monotherapy. Six antiretroviral drugs were selected based on their solubility in N-methyl-2-pyrrolidone and relevance as a combination therapy for HIV treatment or prevention. All drugs released with concentrations above their protein-adjusted inhibitory concentration and retained their physical and chemical properties within the formulation and upon release. The versatility of this formulation to integrate multiple drugs and provide sustained plasma concentrations from several weeks to up to one year, combined with its ability to be removed to terminate the treatment if necessary, makes it attractive as a drug delivery platform technology for a wide range of applications.
在这里，我们报告了一种超长效、可调、可生物降解和可移除的聚合物基递药系统，该系统可为 HIV 的治疗或预防提供长达一年的持续药物输送。这种强大的配方具有将多种药物整合到单次注射中的能力，这对于解决单药治疗的耐药性问题尤为重要。根据其在 N-甲基-2-吡咯烷酮中的溶解度以及作为 HIV 治疗或预防联合治疗的相关性，选择了六种抗逆转录病毒药物。所有药物的释放浓度均高于其蛋白调整抑制浓度，并在配方中和释放后保留其物理和化学性质。该配方具有将多种药物整合并提供数周到长达一年的持续血浆浓度的多功能性，并且如果需要还可以将其移除以终止治疗，因此作为一种药物输送平台技术，它在广泛的应用中具有吸引力。
