School of BioSciences, Faculty of Health & Medical Sciences, Taylor's University, Selangor, Malaysia.
School of Healthcare Sciences, Faculty of Health Sciences, National University of Malaysia, Selangor, Malaysia.
Sci Rep. 2019 Sep 20;9(1):13666. doi: 10.1038/s41598-019-49911-6.
We conducted this cross-sectional population study with a healthy multi-ethnic urban population (n = 577) in Malaysia, combining nutritional assessments with cardiometabolic biomarkers defined by lipid, atherogenic lipoproteins, inflammation and insulin resistance. We found diametrically opposing associations of carbohydrate (246·6 ± 57·7 g, 54·3 ± 6·5%-TEI) and fat (total = 64·5 ± 19·8 g, 31·6 ± 5·5%-TEI; saturated fat = 14·1 ± 2·7%-TEI) intakes as regards waist circumference, HDL-C, blood pressure, glucose, insulin and HOMA2-IR as well as the large-LDL and large-HDL lipoprotein particles. Diets were then differentiated into either low fat (LF, <30% TEI or <50 g) or high fat (HF, >35% TEI or >70 g) and low carbohydrate (LC, <210 g) or high carbohydrate (HC, >285 g) which yielded LFLC, LFHC, HFLC and HFHC groupings. Cardiometabolic biomarkers were not significantly different (P > 0.05) between LFLC and HFLC groups. LFLC had significantly higher large-LDL particle concentrations compared to HFHC. HOMA-IR2 was significantly higher with HFHC (1·91 ± 1·85, P < 0·001) versus other fat-carbohydrate combinations (LFLC = 1·34 ± 1·07, HFLC = 1·41 ± 1·07; LFHC = 1·31 ± 0·93). After co-variate adjustment, odds of having HOMA2-IR >1.7 in the HFHC group was 2.43 (95% CI: 1·03, 5·72) times more compared to LFLC while odds of having large-LDL <450 nmol/L in the HFHC group was 1.91 (95% CI: 1·06, 3·44) more compared to latter group. Our data suggests that a HFHC dietary combination in Malaysian adults is associated with significant impact on lipoprotein particles and insulin resistance.
我们在马来西亚进行了这项横断面人群研究，研究对象为健康的多民族城市人群（n=577），将营养评估与脂质、动脉粥样硬化脂蛋白、炎症和胰岛素抵抗定义的心血管代谢生物标志物相结合。我们发现，碳水化合物（246.6±57.7g，54.3±6.5%-TEI）和脂肪（总量=64.5±19.8g，31.6±5.5%-TEI；饱和脂肪=14.1±2.7%-TEI）摄入量与腰围、HDL-C、血压、血糖、胰岛素和 HOMA2-IR 以及大 LDL 和大 HDL 脂蛋白颗粒呈截然相反的关系。然后，饮食被分为低脂肪（LF，<30%TEI 或 <50g）或高脂肪（HF，>35%TEI 或 >70g）和低碳水化合物（LC，<210g）或高碳水化合物（HC，>285g），分别产生 LFLC、LFHC、HFLC 和 HFHC 分组。心血管代谢生物标志物在 LFLC 和 HFLC 组之间没有显著差异（P>0.05）。与 HFHC 组相比，LFLC 组的大 LDL 颗粒浓度显著升高。与其他脂肪-碳水化合物组合（LFLC=1.34±1.07，HFLC=1.41±1.07；LFHC=1.31±0.93）相比，HFHC 组的 HOMA-IR2 显著升高（1.91±1.85，P<0.001）。在校正协变量后，HFHC 组的 HOMA2-IR>1.7 的比值比（OR）为 2.43（95%CI：1.03，5.72）倍，而 HFHC 组的大 LDL<450 nmol/L 的比值比（OR）为 1.91（95%CI：1.06，3.44）倍。我们的数据表明，马来西亚成年人的 HFHC 饮食组合与脂蛋白颗粒和胰岛素抵抗有显著影响。
