National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology, MOH, National Center for International Research on Tropical Diseases, WHO Collaborating Centre for Tropical Diseases, Shanghai 200025, People's Republic of China.
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology, MOH, National Center for International Research on Tropical Diseases, WHO Collaborating Centre for Tropical Diseases, Shanghai 200025, People's Republic of China.
Acta Trop. 2019 Dec;200:105181. doi: 10.1016/j.actatropica.2019.105181. Epub 2019 Sep 19.
China was once a country plagued by parasitic diseases. At the beginning of the founding of the People's Republic of China, nearly 80% of the population suffered from parasitic diseases because of poverty and poor sanitary conditions. After nearly 70 years of development, China has made remarkable achievements in the prevention and control of parasitic diseases, and the prevalence of parasitic diseases has been greatly reduced. In addition to organizational leadership from the government and various preventive measures, drug treatment and drug research & development are important and irreplaceable links in prevention and control work. Since the 1950s, China has begun to introduce, produce and imitate antiparasitic drugs from abroad, such as santonin, benzimidazole, and praziquantel. Chinese scientists have also contributed to the optimization of production techniques, improvements in drug formulation, the application in the clinic and the mechanisms of actions of generic drugs. At the same time, China has independently developed tribendimidine (TrBD, a broad spectrum anthelminthic), and its anthelminthic spectrum has been comprehensively studied. It is active against almost 20 parasites, is especially superior to benzimidazoles against Necator americanus, and surpasses the effectiveness of praziquantel against Clonorchis sinensis. In the treatment of tapeworm disease, the traditional Chinese medicines pumpkin seeds and betel nuts have good curative effects for taeniasis. Chinese scientists have explored the action modes and clinical administration methods of pumpkin seeds and betel nuts, which is still the main clinical regimen for the disease. This paper reviews the history and progress of the study of anthelmintics in intestinal helminth infections since the founding of the People's Republic of China and aiming to support clinicians and drug researchers in China and other countries.
中国曾经是一个寄生虫病肆虐的国家。中华人民共和国成立之初，由于贫困和卫生条件差，近 80%的人口患有寄生虫病。经过近 70 年的发展，中国在防治寄生虫病方面取得了显著成就，寄生虫病的流行率大大降低。除了政府的组织领导和各种预防措施外，药物治疗和药物研究与开发是防治工作中重要且不可替代的环节。自 20 世纪 50 年代以来，中国开始从国外引进、生产和仿制抗寄生虫药物，如山道年、苯并咪唑和吡喹酮。中国科学家还为优化生产技术、改进药物配方、在临床上的应用以及仿制药的作用机制做出了贡献。同时，中国自主研发了噻苯达唑（TrBD，广谱驱虫药），并对其驱虫谱进行了全面研究。它对近 20 种寄生虫都有活性，对美洲钩虫的疗效尤其优于苯并咪唑类药物，对中华分支睾吸虫的疗效超过吡喹酮。在治疗绦虫病方面，中药南瓜子和槟榔具有良好的疗效。中国科学家探索了南瓜子和槟榔的作用模式和临床给药方法，这仍然是该病的主要临床方案。本文回顾了中华人民共和国成立以来肠道蠕虫感染驱虫药研究的历史和进展，旨在为中国和其他国家的临床医生和药物研究人员提供支持。
