Biological Science and Technology Division, CSIR-North East Institute of Science and Technology (CSIR-NEIST), Jorhat, 785006, Assam, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, Uttar Pradesh, India.
Biological Science and Technology Division, CSIR-North East Institute of Science and Technology (CSIR-NEIST), Jorhat, 785006, Assam, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, Uttar Pradesh, India.
Chem Biol Interact. 2019 Nov 1;313:108824. doi: 10.1016/j.cbi.2019.108824. Epub 2019 Sep 19.
Insect-based bioactive components are emerging as novel sources of drugs, effective against various diseases. Inflammation is considered to be an innate immune response developed by different organisms against foreign pathogens and cellular stress. However, repetitive elevated inflammation is considered to be responsible for development of many other diseases including colitis and arthritis. Due to the limited activities and side effects of non-steroidal anti-inflammatory drugs, researchers are continuously looking for alternative sources of drug molecules to alleviate the inflammatory related complications. Recently, insect-based bioactive components, such as venoms, haemocytes, cecropin A, papiliocin, N-acetyldopamine dimers, cecropin-TY1 peptide, cop A3 peptide, glycosaminoglycan, coprisin peptide, silk fibroin microparticles, and silk fibroin nanoparticles have been found to be active against different inflammatory mechanisms and associated diseases. Cancers, are some of the deadliest diseases, which are mainly treated by chemotherapy, radiation therapy and surgery. However, such treatments, mainly chemotherapy, is associated with enormous side effects. Therefore, as an alternative, less hazardous option, compounds from insects with anti-cancerous activity are being explored. Insect-derived compounds, such as cantharidin, norcantharidin, isocoumarin, plancyols A, plancypyrazine A, pancratistatin, narciclasine, and ungeremine, show potential anti-cancerous activity. In this review, we will be discussing the role of different potential drug molecules of insect origin with special emphasis on anti-inflammation and their association with health disorders and cancer.
昆虫源生物活性成分正成为治疗各种疾病的新型药物来源。炎症被认为是不同生物体针对外来病原体和细胞应激产生的一种固有免疫反应。然而，反复的炎症升高被认为是导致许多其他疾病（包括结肠炎和关节炎）的原因。由于非甾体抗炎药的活性有限且存在副作用，研究人员一直在寻找替代药物分子的来源，以减轻与炎症相关的并发症。最近，昆虫源生物活性成分，如毒液、血淋巴细胞、抗菌肽、抗菌肽、N-乙酰多巴胺二聚体、抗菌肽-TY1 肽、CopA3 肽、糖胺聚糖、Coprisin 肽、丝素微球和丝素纳米颗粒，已被发现对不同的炎症机制和相关疾病具有活性。癌症是一些最致命的疾病，主要通过化疗、放疗和手术治疗。然而，这些治疗方法，主要是化疗，与巨大的副作用有关。因此，作为一种替代的、危害较小的选择，具有抗癌活性的昆虫化合物正在被探索。昆虫衍生化合物，如斑蝥素、去甲斑蝥素、异香豆素、Plancyols A、Plancypyrazine A、Pancratistatin、Narciclasine 和 Ungeremine，显示出潜在的抗癌活性。在这篇综述中，我们将讨论不同潜在的昆虫源药物分子的作用，特别强调它们的抗炎作用及其与健康障碍和癌症的关系。
