Huzhou Key Laboratory of Medical and Environmental Applications Technologies, School of Life Sciences, Huzhou University, Huzhou, China.
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, Huzhou University, Huzhou, China.
Front Immunol. 2024 Aug 23;15:1413179. doi: 10.3389/fimmu.2024.1413179. eCollection 2024.
Inflammation is a normal immune response in organisms, but it often triggers chronic diseases such as colitis and arthritis. Currently, the most widely used anti-inflammatory drugs are non-steroidal anti-inflammatory drugs, albeit they are accompanied by various adverse effects such as hypertension and renal dysfunction. Bioactive peptides (BAPs) provide therapeutic benefits for inflammation and mitigate side effects. Herein, this review focuses on the therapeutic effects of various BAPs on inflammation in different body parts. Emphasis is placed on the immunomodulatory mechanisms of BAPs in treating inflammation, such as regulating the release of inflammatory mediators, modulating MAPK and NF-κB signaling pathways, and reducing oxidative stress reactions for immunomodulation. This review aims to provide a reference for the function, application, and anti-inflammation mechanisms of BAPs.
炎症是生物体的一种正常免疫反应，但它常常引发结肠炎和关节炎等慢性疾病。目前，应用最广泛的抗炎药物是非甾体类抗炎药，尽管它们伴随着各种不良反应，如高血压和肾功能障碍。生物活性肽（BAPs）为炎症提供了治疗益处，并减轻了副作用。本文综述了不同部位的各种 BAPs 对炎症的治疗作用。重点介绍了 BAPs 调节炎症的免疫调节机制，如调节炎症介质的释放、调节 MAPK 和 NF-κB 信号通路以及减轻氧化应激反应等。本文旨在为 BAPs 的功能、应用和抗炎机制提供参考。
