Department of Orthopedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Healthcare Business Groupe, RICOH Company, Ltd., 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Department of Advanced Technology in Medicine, Graduate School of Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Clin Neurophysiol. 2019 Nov;130(11):2114-2123. doi: 10.1016/j.clinph.2019.08.006. Epub 2019 Aug 22.
To visualize neural activity in the brachial plexus using magnetoneurography (MNG).
Using a 124- or 132-channel biomagnetometer system with a superconducting quantum interference device, neuromagnetic fields above the clavicle and neck region were recorded in response to electrical stimulation of the median and ulnar nerves in five asymptomatic volunteers (four men and one woman; age, 27-45 years old). Equivalent currents were computationally reconstructed from neuromagnetic fields and visualized as pseudocolor maps. Reconstructed currents at the depolarization site and compound nerve action potentials (CNAPs) at Erb's point were compared.
Neuromagnetic fields were recorded in all subjects. The reconstructed equivalent currents propagated into the vertebral foramina, and the main inflow levels differed between the median nerve (C5/C6-C7/T1 vertebral foramen) and the ulnar nerve (C7/T1-T1/T2). The inward current peaks at the depolarization site and CNAPs showed high linear correlation.
MNG visualizes neural activity in the brachial plexus and can differentiate the conduction pathways after median and ulnar nerve stimulations. In addition, it can visualize not only the leading and trailing components of intra-axonal currents, but also inward currents at the depolarization site.
MNG is a novel and promising functional imaging modality for the brachial plexus.
利用磁神经图（MNG）可视化臂丛神经的神经活动。
使用具有超导量子干涉装置的 124 或 132 通道生物磁强计系统，在 5 名无症状志愿者（4 名男性和 1 名女性；年龄 27-45 岁）中，记录锁骨和颈部区域上方的神经磁场，以响应正中神经和尺神经的电刺激。从神经磁场计算重建等效电流，并将其可视化为伪彩色图。比较去极化部位的重建电流和 Erb 点的复合神经动作电位（CNAP）。
所有受试者均记录到神经磁场。重建的等效电流传入椎间孔，正中神经（C5/C6-C7/T1 椎间孔）和尺神经（C7/T1-T1/T2）的主要传入水平不同。去极化部位的内向电流峰值和 CNAP 呈高度线性相关。
MNG 可视化了臂丛神经的神经活动，并能区分正中神经和尺神经刺激后的传导途径。此外，它不仅可以可视化轴内电流的前导和尾随分量，还可以可视化去极化部位的内向电流。
MNG 是一种新颖且有前途的臂丛神经功能成像方式。
